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A cross-sectional study of factors related to gastrointestinal drug use in Korean adolescents

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Abstract

Adolescence is critical in the habituation of diverse lifestyles and is a base for future physical well-being. Although gastrointestinal disorders are frequently reported in adolescents, studies related to GI drug use or related factors in Korean adolescents are rare. Thus, this study examined Korean adolescents for the use of GI drugs for abdominal symptoms and analyzed the associated factors. This cross-sectional study was done with a total of 2,416 students who completed a given questionnaire. The health-related questions included GI medication intake, smoking, alcohol, caffeine, regular exercise, self-cognitive health level, GI symptom, non-steroidal anti-inflammatory drugs (NSAIDs) intake, and sleep problems. In questions about GI medication intake, drugs included digestives and antacids. And the intake of GI drugs more than once during the past 1 month was regarded as taking GI drugs. The sociodemographic questions included age, gender, grade, number of close friends, extracurricular activities, and school performance. The overall prevalence for taking GI drugs, including antacids and digestives, was 17.4 %. When students taking GI drugs were compared with those not taking GI drugs, the former group showed higher rates of girls (P < 0.001) and participants in extracurricular activities (P < 0.05) than the latter group. Factors including alcohol, caffeine, self-cognitive health levels, and GI symptoms showed statistical significance with the rate of GI drug intake. The rate of GI drug intake in NSAID users was 2.7 times higher than that in non-users (P < 0.001). The prevalence rate of every sleep problem was higher in students taking GI medications except snoring, witnessed apnea, and teeth grinding. From the multiple regression, it was found that gender (female), extracurricular activities, alcohol intake, self-cognitive health levels, NSAIDs intake, and nightmares were related factors to GI drug intake. Based on the results, it was conclude that encouragement to build healthy lifestyle habits in adolescents is very important for their academic performances and health status in adulthood.

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References

  • Apley, J., and N. Naish. 1958. Recurrent abdominal pains: a field survey of 1000 school children. Archives of Disease in Childhood 33: 165–170.

    Article  PubMed  CAS  Google Scholar 

  • Bode, C., and J.C. Bode. 1997. Alcohol’s role in gastrointestinal tract disorders. Alcohol Health and Research World 21: 76–83.

    PubMed  CAS  Google Scholar 

  • Bruley des Varannes, S., G. Errieau, and C. Tessier. 2007. Two thirds of patients with gastroesophageal reflux have nocturnal symptoms: survey by 562 general practitioners of 36,663 patients. La Presse Médicale 36: 591–597.

    Article  PubMed  Google Scholar 

  • Choi, K., H. Son, M. Park, J. Han, K. Kim, B. Lee, and H. Gwak. 2009. Internet overuse and excessive daytime sleepiness in adolescents. Psychiatry and Clinical Neurosciences 63: 455–462.

    Article  PubMed  Google Scholar 

  • Dore, M.P., E. Maragkoudakis, K. Fraley, A. Pedroni, V. Tadeu, G. Realdi, D.Y. Graham, G. Delitala, and H.M. Malaty. 2008. Diet, lifestyle and gender in gastro-esophageal reflux disease. Digestive Diseases and Sciences 53: 2027–2032.

    Article  PubMed  Google Scholar 

  • El-Serag, H.B., P. Richardson, P. Pilgrim, and M.A. Gilger. 2007. Determinants of gastroesophageal reflux disease in adults with a history of childhood gastroesophageal reflux disease. Clinical Gastroenterology and Hepatology 5: 696–701.

    Article  PubMed  Google Scholar 

  • Eslick, G.D., and N.J. Talley. 2009. Gastroesophageal reflux disease (GERD): risk factors, and impact on quality of life-a population-based study. Journal of Clinical Gastroenterology 43: 111–117.

    Article  PubMed  Google Scholar 

  • Fillingim, R.B., C.D. King, M.C. Ribeiro-Dasilva, B. Rahim-Williams, and J.L. Riley 3rd. 2009. Sex, gender, and pain: a review of recent clinical and experimental findings. Journal of Pain 10: 447–485.

    Article  PubMed  Google Scholar 

  • Gunasekaran, T.S., M. Dahlberg, P. Ramesh, and G. Namachivayam. 2008. Prevalence and associated features of gastroesophageal reflux symptoms in a caucasian- predominant adolescent school population. Digestive Diseases and Sciences 53: 2373–2379.

    Article  PubMed  CAS  Google Scholar 

  • Hyams, J.S., G. Burke, P.M. Davis, B. Rzepski, and P.A. Andrulonis. 1996. Abdominal pain and irritable bowel syndrome in adolescents; a community-based study. Journal of Pediatrics 129: 200–226.

    Google Scholar 

  • Johns, M.W. 1991. A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep 14: 540–545.

    PubMed  CAS  Google Scholar 

  • Kadakia, S.C., J.W. Kikendall, C. Maydonovitch, and L.F. Johnson. 1995. Effect of cigarette smoking on gastroesophageal reflux measured by 24-h ambulatory esophageal pH monitoring. American Journal of Gastroenterology 90: 1785–1790.

    PubMed  CAS  Google Scholar 

  • Kahrilas, P.J., and R.R. Gupta. 1990. Mechanisms of acid reflux associated with cigarette smoking. Gut 31: 4–10.

    Article  PubMed  CAS  Google Scholar 

  • Kwon, H.J., D.Y. Yi, E. Ryoo, K.H. Cho, D.W. Son, and H. Tcha. 2008. Prevalence and risk factors associated with esophagitis in children with abdominal pain. Korea Journal of Pediatric Gastroenterology and Nutrition 11: 103–109.

    Google Scholar 

  • Lacy, C.F., L.L. Armstrong, M.P. Goldman, and L.L. Lance. 2009. Drug information handbook, 18th ed. Ohio: Lexi-Comp Inc.

    Google Scholar 

  • Lamberg, L. 2000. Sleep disorders, often unrecognized, complicate many physical illnesses. JAMA 284: 2173–2175.

    Article  PubMed  CAS  Google Scholar 

  • Locke, G.R., N.J. Talley, S.L. Fett, A.R. Zinsmeister, and L.J. Melton. 1999. Risk factors associated with symptoms of gastroesophageal reflux. American Journal of Medicine 106: 642–649.

    Article  PubMed  Google Scholar 

  • Lu, C.L., H.C. Lang, F.Y. Chang, T.J. Chen, C.Y. Chen, J.C. Luo, and S.D. Lee. 2005. Social and medical impact, sleep quality and the pharmaceutical costs of heartburn in Taiwan. Alimentary Pharmacology and Therapeutics 22: 739–747.

    Article  PubMed  Google Scholar 

  • Moon, J.Y., and K.R. Moon. 2007. The relationship of between anxiety tendency and recurrent abdominal pain in elementary school children. Korea Journal of Pediatric Gastroenterology and Nutrition 10: 129–137.

    Google Scholar 

  • Nelson, S.P., E.H. Chen, G.M. Syniar, and K.K. Christoffel. 2000. Prevalence of symptoms of gastroesophageal reflux during childhood. Archives of Pediatrics and Adolescent Medicine 154: 150–154.

    Article  PubMed  CAS  Google Scholar 

  • Nilsson, M., R. Johnson, W. Ye, K. Hveem, and J. Lagergren. 2004. Lifestyle related risk factors in the aetiology of gastroesophageal reflux. Gut 53: 1730–1735.

    Article  PubMed  CAS  Google Scholar 

  • Olafsdottir, L.B., H. Gudjonsson, H.H. Jonsdottir, and B. Thjodleifsson. 2011. Natural history of heartburn: a 10-year population-based study. World Journal of Gastroenterology 17: 639–645.

    Article  PubMed  Google Scholar 

  • Waring, J.P., T.F. Eastwood, J.M. Austin, and R.A. Sanowski. 1989. The immediate effects of cessation of cigarette smoking on gastroesophageal reflux. American Journal of Gastroenterology 84: 1076–1078.

    PubMed  CAS  Google Scholar 

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Acknowledgements

This work was supported by the Ewha Womans University Research Grant of 2012.

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We declare no conflict of interest.

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Authors and Affiliations

  1. College of Pharmacy and Division of Life & Pharmaceutical Sciences, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-gu, Seoul, 120-750, Korea

    Kyung Eun Lee, Hye Sun Gwak, Byung Koo Lee, Seung Jin Bae & Sandy Rhie

  2. Graduate School of Clinical Health Sciences, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-gu, Seoul, 120-750, Korea

    Se Jung Hwang, Hye Sun Gwak, Byung Koo Lee, Seung Jin Bae & Sandy Rhie

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  1. Kyung Eun Lee
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  2. Se Jung Hwang
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  3. Hye Sun Gwak
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  4. Byung Koo Lee
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  5. Seung Jin Bae
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Correspondence to Sandy Rhie.

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Lee, K.E., Hwang, S.J., Gwak, H.S. et al. A cross-sectional study of factors related to gastrointestinal drug use in Korean adolescents. Arch. Pharm. Res. 36, 1238–1243 (2013). https://doi.org/10.1007/s12272-013-0220-5

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