Abstract
The phytochemical investigation of Rudbeckia laciniata L. obtained a new flavonol glycoside (1), together with four flavonol glycosides (2–5) and eight quinic acid derivatives (6–13). The structure was elucidation by means of spectroscopic methods and chemical evidence. The isolated compounds were tested for cytotoxicity against four human tumor cell lines in vitro using the sulforhodamine B bioassay.
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Ahn, B.G., J.M. Hur, and J.C. Park. 2007. Isolations of flavonoids and a higher alcohol from the aerial parts of Brassica juncea. Korean Journal of Pharmacognosy 38: 254–257.
Barrett, B. 2003. Medicinal properties of Echinacea: A critical review. Phytomedicine 10: 66–86.
Basnet, P., K. Matsushige, K. Hase, S. Kadota, and T. Namba. 1996. Four di-O-caffeoyl quinic acid derivatives from propolis potent hepatoprotective activity in experiment liver injury models. Biological and Pharmaceutical Bulletin 19: 1479–1484.
Bohlmann, F., J. Jakupovic, and C. Zdero. 1978. Neue norsesquiterpene aus Rudbeckia laciniata und Senecio paludaffinis. Phytochemistry 17: 2034–2036.
Fukushi, Y., C. Yajima, and J. Mizutani. 1994. Prelacinan-7-ol, a novel sesquiterpene from Rudbeckia laciniata. Tetrahedron Letters 35: 8809–8812.
Fukushi, Y., C. Yajima, J. Mizutani, and S. Tahara. 1998. Tricyclic sesquiterpenes from Rudbeckia laciniata in honor of Professor G. H. NEIL TOWERS 75th birthday. Phytochemistry 49: 593–600.
Jakupovic, J., Y. Jia, R.M. King, and F. Bohlmann. 1986. Rudbeckiolid, ein dimeres Sesquiterpenlaction aus Rudbeckia laciniata. Liebigs Annalen der Chemie 8: 1474–1477.
Kim, D.K. 2001. Antioxidative compounds from the aerial parts of Lactuca scariola L. Archives of Pharmacal Research 24: 427–430.
Kim, K.H., Y.H. Kim, and K.R. Lee. 2007. Isolation of quinic acid derivatives and flavonoids from the aerial parts of Lactuca indica L. and their hepatoprotective activity in vitro. Bioorganic and Medicinal Chemistry Letters 17: 6739–6743.
Latza, S., D. Ganber, and R.G. Berger. 1996. Carbohydrated esters of cinnamic acid from fruits of Physalis Peruviana, Psidium Guajava, and Vaccinium vitis-Idaea. Phytochemisty 43: 481–485.
Lee, S.Y., K.W. Woo, C.S. Kim, D.U. Lee, and K.R. Lee. 2013. New lignans from the aerial parts of Rudbeckia laciniata. Helvetica Chimica Acta 96: 320–325.
Lee, T.B. 2003. Coloured flora of Korea, 350. Seoul: Hyang-Moon Publishing Co.
Mabry, T.J., K.R. Markham, and B.M. Thomas. 1970. The systematic identification of flavonoids, Chapter 5, 39–61. New York: Springer.
Nunes, F.M., A. Reis, A.M.S. Silva, M. Rosario, M. Domingues, and M.A. Coimbra. 2008. Rhamnoarabinosyl and rhamnoarabinoarabinosyl side chains as structural features of coffee arabinogalactans. Phytochemisty 69: 1573–1585.
Skehan, P., R. Storeng, D. Scudiero, A. Monks, J. Mcmahon, D. Vistica, J.T. Warren, H. Bokesch, S. Kenney, and M.R. Boyd. 1990. New colorimetric cytotoxicity assay for anticancer-drug screening. Journal of the National Cancer Institute 82: 1107–1112.
Takemura, M., R. Nishida, N. Mori, and Y. Kuwahara. 2002. Acylated flavonol glycosides as probing stimulants of a bean aphid, Megoura crassicauda, from Vicia angustifolia. Phytochemistry 61: 135–140.
Yeom, S.H., M.K. Kim, H.J. Kim, J.G. Shim, J.H. Lee, and M.W. Lee. 2003. Phenolic compounds from seeds of Astragalus sinicus and its antioxidative activities. Korean Journal of Pharmacognosy 34: 344–351.
Young, H.S., J.C. Park, H.J. Park, J.H. Lee, and J.S. Choi. 1991. Phenolic compounds of the leaves of Eucommia ulmoides. Archives of Pharmacal Research 14: 114–117.
Zahid, M., A. Ali, O. Ishurd, A. Ahmed, Z. Ali, V.U. Ahmed, and Y. Pan. 2002. New cycloartane and flavonol glycosides from Corchorus depressus. Helvetica Chimica Acta 85: 689–697.
Acknowledgments
This study was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (20110028285). The authors would like to thank Mr. Do Kyun Kim, Dr. Eun Jung Bang, and Dr. Jung Ju Seo at the Korea Basic Science Institute for the NMR and MS spectra measurements.
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Lee, S.Y., Shin, Y.J., Choi, S.U. et al. A new flavonol glycoside from the aerial part of Rudbeckia laciniata . Arch. Pharm. Res. 37, 834–838 (2014). https://doi.org/10.1007/s12272-013-0199-y
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DOI: https://doi.org/10.1007/s12272-013-0199-y