Abstract
Four lignans, meso-dihydroguaiaretic acid (DHGA), macelignan, fragransin A2 and nectandrin B, were isolated from the seeds of Myristica fragrans (Vietnamese nutmeg) and investigated for their cytotoxic activity against eight cancer cell lines. Of these, DHGA exhibited potent cytotoxicity against H358 with IC50 value of 10.1 μM. In addition, DHGA showed antitumor activity in allogeneic tumor-bearing mice model.
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Acknowledgments
This research is funded by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under Grant number 106.99.99.09. This research was also supported by a Grant from the Global R&D Center (GRDC) Program through the NRF funded by the MEST and by a Grant from the KRIBB Research Initiative Program. This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2009-0093815).
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Thuong, P.T., Hung, T.M., Khoi, N.M. et al. Cytotoxic and anti-tumor activities of lignans from the seeds of Vietnamese nutmeg Myristica fragrans . Arch. Pharm. Res. 37, 399–403 (2014). https://doi.org/10.1007/s12272-013-0185-4
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DOI: https://doi.org/10.1007/s12272-013-0185-4