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Alkaloids from Lycoris caldwellii and their particular cytotoxicities against the astrocytoma and glioma cell lines

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Abstract

Phytochemical investigation of the ethanol extract of the bulbs of Lycoris caldwellii afforded four new alkaloids, (+)-N-methoxylcarbonyl-nandigerine (1), (+)-N-methoxycarbonyl-lindcarpine (2), (+)-10-O-methylhernovine N-oxide (3), and (+)-3-hydroxy-anhydrolycorine N-oxide (4). Structural elucidation of all the compounds were performed by spectral methods such as 1D and 2D (1H-1H COSY, HMQC, and HMBC) NMR spectroscopy, in addition to high resolution mass spectrometry. All the alkaloids were in vitro evaluated for their cytotoxic activities against eight tumor cell lines (BEN-MEN-1, CCF-STTG1, CHG-5, SHG-44, U251, BGC-823, HepG2, and SK-OV-3). Alkaloids 1 and 2 exhibited particular cytotoxic activities against astrocytoma and glioma cell lines with IC50 of 9.2–11.3 μM and 10.4–12.2 μM respectively.

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Authors and Affiliations

  1. Department of Neurosurgery, Institue of Neurology, General Hospital of Shenyang Military Area Command, #83 Wenhua Road, Shenhe District, Shenyang, 110018, China

    Peng Cao, Dong-Sheng Pan, Song Han, Chun-Yong Yu & Yong Liang

  2. Department of Organic Chemistry, College of Pharmacy, Second Military Medical University, Guohe Road 325, Shanghai, 200433, People’s Republic of China

    Qing-Jie Zhao

  3. Department of Pharmacy, 455 Hospital of People’s Liberation Army, Shanghai, 200052, China

    Yan Song

Authors
  1. Peng Cao
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  2. Dong-Sheng Pan
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  3. Song Han
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  4. Chun-Yong Yu
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  5. Qing-Jie Zhao
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  6. Yan Song
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  7. Yong Liang
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Correspondence to Yan Song or Yong Liang.

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Cao, P., Pan, DS., Han, S. et al. Alkaloids from Lycoris caldwellii and their particular cytotoxicities against the astrocytoma and glioma cell lines. Arch. Pharm. Res. 36, 927–932 (2013). https://doi.org/10.1007/s12272-013-0089-3

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  • DOI: https://doi.org/10.1007/s12272-013-0089-3

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