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Two new tirucallane triterpenoids from the leaves of Aquilaria sinensis

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Abstract

Two new tirucallane triterpenoids, aquilacallanes A–B (1–2), together with 15 known compounds (3–17) were isolated from the leaves of Aquilaria sinensis. The structures of these new compounds were elucidated on the basis of extensive spectroscopic analyses. All compounds were evaluated for their cytotoxic activity against five human cancer cell lines. The known compounds, ursolic acid (7) and 5,7,4′-trimethoxyflavone (14), exhibited weak cytotoxic activity against some cells.

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Acknowledgments

This work was financially supported by the National Basic Research Program of China (973 Program Nos. 2011CB915503 and 2009CB522303), the National Natural Science Foundation of China (No. U0932602), and the State Key Laboratory of Phytochemistry and Plant Resources in West China (No. P2010-ZZ05).

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Authors and Affiliations

  1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650204, People’s Republic of China

    Jin Tang Cheng, Juan He, Xing De Wu, Liao Bin Dong, Li Yan Peng, Yan Li & Qin Shi Zhao

  2. College of Pharmacology, Kunming Medical University, Kunming, 650031, People’s Republic of China

    Ya Qiong Han

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  1. Jin Tang Cheng
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  2. Ya Qiong Han
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  3. Juan He
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  4. Xing De Wu
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  5. Liao Bin Dong
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  6. Li Yan Peng
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  7. Yan Li
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  8. Qin Shi Zhao
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Correspondence to Qin Shi Zhao.

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Cheng, J.T., Han, Y.Q., He, J. et al. Two new tirucallane triterpenoids from the leaves of Aquilaria sinensis . Arch. Pharm. Res. 36, 1084–1089 (2013). https://doi.org/10.1007/s12272-013-0088-4

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  • DOI: https://doi.org/10.1007/s12272-013-0088-4

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