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Site-selective reactions of hydrazonoyl chlorides with cyanoacetic hydrazide and its N-arylidene derivatives and anti-aggressive activity of prepared products

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Abstract

Reactions of hydrazonoyl halides with cyanoacetic hydrazide and its N-arylidene derivatives proceeded site-selectively and afforded the respective pyrazolo[3,4-d]pyridazine and aldehyde N-(1-aryl-3-acetyl-4-cyanopyrazol-5-yl)hydrazone derivatives. The structures of the products were elucidated on the basis of their spectral and elemental analyses. The anti-aggressive activity of the compounds prepared was screened.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, University of Cairo, Giza, 12613, Egypt

    Ahmad Sami Shawali, Thoraya A. Farghaly & Shadia M. Hussein

  2. Research Unit, Saco Pharm. Co, 6th October City, Giza, Egypt

    Mohamed M. Abdalla

Authors
  1. Ahmad Sami Shawali
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  2. Thoraya A. Farghaly
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  3. Shadia M. Hussein
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  4. Mohamed M. Abdalla
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Correspondence to Ahmad Sami Shawali.

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Shawali, A.S., Farghaly, T.A., Hussein, S.M. et al. Site-selective reactions of hydrazonoyl chlorides with cyanoacetic hydrazide and its N-arylidene derivatives and anti-aggressive activity of prepared products. Arch. Pharm. Res. 36, 694–701 (2013). https://doi.org/10.1007/s12272-013-0082-x

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