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Anti-Inflammatory Effect of Pristimerin on Lipopolysaccharide-Induced Inflammatory Responses in Murine Macrophages

Archives of Pharmacal Research volume 36, pages 495–500 (2013)Cite this article

Abstract

Pristimerin, a quinonemethide triterpenoid derived from Celastraceae and Hippocrateaceae, has recently been found to suppress tumor promotion, metastasis and angiogenesis. In the present study, we evaluated the anti-inflammatory potentials of pristimerin in a cell culture system. Pristimerin suppressed not only the generation of nitric oxide (NO) and prostaglandin E2, but also the expression of inducible NO synthase and cyclooxygenase-2 induced by lipopolysacharide (LPS) in murine macrophage RAW264.7 cells. Similarly, pristimerin inhibited the release of pro-inflammatory cytokines, namely, tumor necrosis factor-α and interleukin-6, induced by LPS. The underlying mechanism of the anti-inflammatory action of pristimerin was correlated with down-regulation of nuclear factor-κB and the mitogen-activated protein kinase signal pathway.

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Acknowledgments

This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MEST) (No. 2011-0028637) and the RIC Program of MKE.

Conflict of interest

The authors declare that they have no competing interests.

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Affiliations

  1. Department of Biomedical Science, College of Natural Science, Catholic University of Daegu, 330 Geumrak-Ri, Gyeoungsan-Si, 700-712, Republic of Korea

    Hyeon Jin Kim, Geun Mook Park & Jin-Kyung Kim

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  1. Hyeon Jin Kim
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  2. Geun Mook Park
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  3. Jin-Kyung Kim
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Correspondence to Jin-Kyung Kim.

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Kim, H.J., Park, G.M. & Kim, JK. Anti-Inflammatory Effect of Pristimerin on Lipopolysaccharide-Induced Inflammatory Responses in Murine Macrophages. Arch. Pharm. Res. 36, 495–500 (2013). https://doi.org/10.1007/s12272-013-0054-1

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  • DOI: https://doi.org/10.1007/s12272-013-0054-1

Keywords

  • Pristimerin
  • Inflammation
  • Nuclear factor-kappa B
  • Mitogen-activated protein kinase
  • Inflammatory response