Multiple biological properties of macelignan and its pharmacological implications

Abstract

Macelignan found in the nutmeg mace of Myristica fragrans obtains increasing attention as a new avenue in treating various diseases. Macelignan has been shown to possess a spectrum of pharmacological activities, including anti-bacterial, anti-inflammatory, anti-cancer, anti-diabetes, and hepatoprotective activities; recently, it has also been shown to have neuroprotective activities. This review summarizes the current research on the biological effects of macelignan derived from M. fragrans, with emphasis on the importance in understanding and treating complex diseases such as cancer and Alzheimer’s disease.

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Acknowledgments

This paper was supported by Konkuk University research support program (2011)

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Correspondence to Jung-Soo Han.

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Paul, S., Hwang, J.K., Kim, H.Y. et al. Multiple biological properties of macelignan and its pharmacological implications. Arch. Pharm. Res. 36, 264–272 (2013). https://doi.org/10.1007/s12272-013-0048-z

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Keywords

  • Nutmeg
  • Macelignan
  • Myristica fragrans
  • Pharmacological properties
  • Neurodegenerative disease