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Efficacy of sesamol on plasma and tissue lipids in isoproterenol-induced cardiotoxicity in wistar rats

Archives of Pharmacal Research volume 35, pages 1465–1470 (2012)Cite this article

Abstract

Myocardial infarction is the leading cause of death all over the world. Sesamol is a potent phenolic antioxidant contained only in processed sesame oil and possesses potent chemopreventive, antimutagenic, antihepatotoxic and antioxidation properties. This study was undertaken to investigate the effect of sesamol on plasma and tissue lipid profiles in isoproterenol (ISO) — induced rats. Myocardial infarction was induced in adult male albino rats of the Wistar strain, weighing 180–200 g, by administration of isoproterenol (85 mg/kg of body weight), subcutaneously for 2 consecutive days. Sesamol dissolved in saline (0.9% NaCl) was administered intraperitoneally once in a day in the morning for 7 days. Increased levels of total cholesterol, phospholipids, triglycerides and free fatty acids in the plasma and the decreased levels of phospholipids in tissues were observed in ISO-induced rats. Very low density lipoprotein cholesterol (VLDL-C) and low density lipoprotein cholesterol (LDL-C) increased while high density lipoprotein cholesterol (HDL-C) decreased in the plasma of ISO-induced rats. Administration of sesamol (50, 100 and 200 mg/kg of body weight) improved the above changes and brought towards normal level. The protective role of sesamol against isoproterenol-induced myocardial infarction was further confirmed by histopathological examination. These results suggest that sesamol has antihyperlipidaemic effect against cardiotoxicity.

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Affiliations

  1. Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, 608 002, Tamil Nadu, India

    Lakshmanan Vennila & Kodukkur Viswanathan Pugalendi

  2. Department of Biochemistry & Biotechnology, Annamalai University, Annamalainagar, 608 002, Tamil Nadu, India

    Kodukkur Viswanathan Pugalendi

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  1. Lakshmanan Vennila
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  2. Kodukkur Viswanathan Pugalendi
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Correspondence to Kodukkur Viswanathan Pugalendi.

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Vennila, L., Pugalendi, K.V. Efficacy of sesamol on plasma and tissue lipids in isoproterenol-induced cardiotoxicity in wistar rats. Arch. Pharm. Res. 35, 1465–1470 (2012). https://doi.org/10.1007/s12272-012-0817-0

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  • DOI: https://doi.org/10.1007/s12272-012-0817-0

Key words

  • Myocardial infarction
  • Isoproterenol
  • Sesamol
  • Lipid profile