Abstract
Eighteen new 4-[2-amino-3-cyano-5-oxo-4-substitutedaryl-4H-indeno[1,2-b]pyridin-1-(5H)-yl]benzenesulfonamide derivatives 6a–q were synthesized via a reaction of aromatic aldehydes, enaminone 3 and malononitrile in one-pot reaction. Also, compounds 6a–q were obtained, via another route by reaction of enaminone 3 with arylidenemalononitriles 4a–q. The structure of the synthesized compounds was characterized by microanalysis, IR, 1H-NMR, 13C-NMR and mass spectral data. All the target compounds were subjected to in vitro anticancer activity against breast cancer cell line (MCF7). Compound 6d showed a higher potency with IC50 value (4.34 μM) than that of the Doxorubicin (5.40 μM), as the reference drug, while compound 6n with IC50 value (6.84 μM) is nearly as active as Doxorubicin. Also, compounds 6a–c, 6e, 6f, 6h and 6p exhibited a moderate activity, while compounds 3, 6g, 6i–m, 6o and 6q showed weak activity.
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Ghorab, M.M., Al-Said, M.S. Anticancer activity of novel indenopyridine derivatives. Arch. Pharm. Res. 35, 987–994 (2012). https://doi.org/10.1007/s12272-012-0605-x
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DOI: https://doi.org/10.1007/s12272-012-0605-x