Abstract
Design, synthesis and insight into the structure-activity relationships (SAR) of phytosterol analogues as novel antiapoptotic agents are described. In particular, the non-branched alkyl chain at C24 and the pseudosugar moiety at C3 hydroxyl group turned out crucial for the inhibition of human umbilical vein endothelial cells (HUVEC) apoptosis.
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Lee, S., Marharjan, S., Jung, JW. et al. Novel human umbilical vein endothelial cells (HUVEC)-apoptosis inhibitory phytosterol analogues: Insight into their structure-activity relationships. Arch. Pharm. Res. 35, 455–460 (2012). https://doi.org/10.1007/s12272-012-0308-3
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DOI: https://doi.org/10.1007/s12272-012-0308-3