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Protective constituents against sepsis in mice from the root barks of Ulmus davidiana var. japonica

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Abstract

In the course of isolating preventive agents against sepsis based on the in vivo assay model, eleven known compounds, (−)-catechin (1), catechin-7-O-β-apiofuranoside (2), catechin-7-O-α-Lrhamnopyranoside (3), catechin-3-O-α-L-rhamnopyranoside (4), catechin-7-O-β-d-glucopyranoside (5), butyl (+)-5′-methoxyisolariciresinol-9′-O-β-d-xylopyranoside (6), lyoniside (7), nudiposide (8), α-nigerose (9), butyl α-d-fructofuranoside (10), and procyanidin B3 (11) were isolated from the root barks of Ulmus davidiana var. japonica. Compounds 2, 6, and 8 significantly protected against sepsis in a mouse model with survival rates of mice exposed to 10 mg/kg of LPS/d-GalN ranged from 80%–100%. Among them, 8 exhibited the most potent protective effect and decreased the plasma levels of TNF-α, IL-10 and ALT activity.

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References

  • Altavilla, D., Squadrito, G., Minutoli, L., Deodato, B., Bova, A., Sardella, A., Seminara, P., Passaniti, M., Urna, G., Venuti, S. F., Caputi, A. P., and Squadrito, F., Inhibitory of nuclear factor-kappaB activation by IRFI 042, protects against endotoxin-induced shock. Cardiovasc. Res., 54, 684–693 (2002).

    Article  PubMed  CAS  Google Scholar 

  • Bone, R. C., Balk, R. A., Cerra, F. B., Dellinger, R. P., Fein, A. M., Knaus, W. A., Schein, R. M., and Sibbald, W. J., Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Chest, 101, 1644–1655 (1992).

    Article  PubMed  CAS  Google Scholar 

  • Deitch, E. A., Animal models of sepsis and shock: a review and lessons learned. Shock, 9, 1–11 (1998).

    Article  PubMed  CAS  Google Scholar 

  • Foo, L. Y. and Karchesy, J. J., Polyphenolic glycosides from Douglas fir inner bark. Phytochemistry, 28, 1237–1240 (1989).

    Article  CAS  Google Scholar 

  • Goffin, D., Bystricky, P., Shashkov, A. S., Lynch, M., Hanon, E., Paquot, M., and Savage, A. V., A systematic NMR determination of α-D-glucooligosaccharides, effect of linkage type, anomeric configuration and combination of different linkages type on 13C chemical shifts for the determination of unknown isomaltooligosaccharides. Bull. Korean Chem. Soc., 30, 2535–2541 (2009).

    Article  CAS  Google Scholar 

  • Herbert, J. M., Fraisse, L., Bachy, A., Valette, G., Savi, P., Laplace, M. C., Lassalle, J., Roche, B., Lale, A., and Keane, P. E., Biochemical and pharmacological properties of SR 27388, a dual antioxidant and PAF receptor antagonist. J. Lipid Mediat., 8, 31–51 (1993).

    PubMed  CAS  Google Scholar 

  • Hewett, J. A. and Roth, R. A., Hepatic and extrahepatic pathobiology of bacterial lipopoly-saccharides. Pharmacol. Rev., 45, 381–509 (1993).

    CAS  Google Scholar 

  • Inoshiri, S., Sasaki, M., Kohda, H., Otsuka, H., and Yamasaki, K., Aromatic glycosides from Berchemia racemosa. Phytochemistry, 26, 2811–2814 (1987).

    Article  CAS  Google Scholar 

  • Ishimaru, K., Nonaka, G. I., and Nishioka, I., Flavan-3-ol and procyanidin glycosides from Quercus miyagii. Phytochemistry, 26, 1167–1170 (1987).

    Article  CAS  Google Scholar 

  • Jin, U. H., Lee, D. Y., Kim, D. S., Lee, I. S., and Kim, C. H., Induction of mitochondria-mediated apoptosis by methanol fraction of Ulmus davidiana Planch (Ulmaceae) in U87 glioblastoma cells. Environ. Toxicol. Pharmacol., 22, 136–141 (2006).

    Article  PubMed  CAS  Google Scholar 

  • Jin, U. H., Suh, S. J., Park, S. D., Kim, K. S., Kwon, D. Y., and Kim, C. H., Inhibition of mouse osteoblast proliferation and prostaglandin E2 synthesis by Ulmus davidiana Planch (Ulmaceae). Food Chem. Toxicol., 46, 2135–2142 (2008).

    Article  PubMed  CAS  Google Scholar 

  • Jun, C. D., Pae, H. O., Kim, Y. C., Jeong, S. J., Yoo, J. C., Lee, E. J., Choi, B. M., Chae, S. W., Park, R. K., and Chung, H. T., Inhibition of nitric oxide synthesis by butanol fraction of the methanol extract of Ulmus davidiana in murine macrophages. J. Ethnopharmacol., 62, 129–135 (1998).

    Article  PubMed  CAS  Google Scholar 

  • Kang, S. K., Kim, K. S., Byun, Y. S., Suh, S. J., Jin, U. H., Kim, K. H., Lee, I. S., and Kim, C. H., Effects of Ulmus davidiana planch on mineralization, bone morphogenetic protein-2, alkaline phosphatase, type I collagen, and collagenase-1 in bone cells. In Vitro Cell. Dev. Biol. Anim., 42, 225–229 (2006).

    Article  PubMed  Google Scholar 

  • Kohler, N., Wray, V., and Winterhalter, P., Preparative isolation of procyanidins from grape seed extracts by highspeed counter-current chromatography. J. Chromatogr. A, 1177, 114–125 (2008).

    Article  PubMed  CAS  Google Scholar 

  • Kubes, P. and McCafferty, D. M., Nitric oxide and intestinal inflammation. Am. J. Med., 109, 150–158 (2000).

    Article  PubMed  CAS  Google Scholar 

  • Lee, M. K., Sung, S. H., Lee, H. S., Cho, J. H., and Kim, Y. C., Lignan and neolignan glycosides from Ulmus davidiana var. japonica. Arch. Pharm. Res., 24, 198–201 (2001).

    Article  PubMed  CAS  Google Scholar 

  • Lee, S. W., Li, G., Lee, K. S., Jung, J. S., Xu, M. L., Seo, C. S., Chang, H. W., Kim, S. K., Song, D. K., and Son, J. K., Preventive agents against sepsis and new phenylpropanoid glucosides from the fruits of Illicium verum. Planta Med., 69, 861–864 (2003).

    Article  PubMed  CAS  Google Scholar 

  • Li, G., Seo, C. S., Lee, K. S., Kim, H. J., Chang, H. W., Jung, J. S., Song, D. K., and Son, J. K., Protective constituents against sepsis in mice from the root cortex of Paeonia suffruticosa. Arch. Pharm. Res., 27, 1123–1126 (2004).

    Article  PubMed  CAS  Google Scholar 

  • Moon, Y. H. and Rim, G. R., Studies on the constituents of Ulmus parvifolia. Korean J. Pharm., 26, 1–7 (1995).

    CAS  Google Scholar 

  • Na, M. K., An, R. B., Lee, S. M., Min, B. S., Kim, Y. H., Bae, K. H., and Kang, S. S., Antioxidant compounds from the stem bark of Sorbus commixta. Nat. Prod. Sci., 8, 26–29 (2002).

    CAS  Google Scholar 

  • Nahrstedt, A., Proksch, P., and Conn, E. E., (−)-Catechin, flavonol glycosides and flavones from Chamaebatia foliolosa. Phytochemistry, 26, 1546–1547 (1987).

    Article  CAS  Google Scholar 

  • Novogrodsky, A., Vanichkin, A., Patya, M., Gazit, A., Osherov, N., and Levitzki, A., Prevention of lipopolysaccharide-induced lethal toxicity by tyrosine kinase inhibitors. Science, 264, 1319–1322 (1994).

    Article  PubMed  CAS  Google Scholar 

  • Seo, C. S., Lee, Y. K., Kim, Y. J., Jung, J. S., Jahng, Y., Chang, H. W., Song, D. K., and Son, J. K., Protective effect of lignans against sepsis from the roots of Saururus chinensis. Biol. Pharm. Bull., 31, 523–526 (2008).

    Article  PubMed  CAS  Google Scholar 

  • Smite, E., Pan, H., and Lundgren, L. N., Lignan glycosides from inner bark of Betula pendula. Phytochemistry, 40, 341–343 (1995).

    Article  CAS  Google Scholar 

  • Song, D. K., Kim, J. Y., Li, G., Lee, K. S., Seo, C. S., Yan, J. J., Jung, J. S., Kim, H. J., Chang, H. W., and Son, J. K., Agents protecting against sepsis from the roots of Angelica dahurica. Biol. Pharm. Bull., 28, 380–382 (2005).

    Article  PubMed  CAS  Google Scholar 

  • Suh, S. J., Yun, W. S., Kim, K. S., Jin, U. H., Kim, J. K., Kim, M. S., Kwon, D. Y., and Kim, C. H., Stimulative effect of Ulmus davidiana Planch (Ulmaceae) on osteoblastic MC3T3-E1 cells. J. Ethnopharmacol., 109, 480–485 (2007).

    Article  PubMed  Google Scholar 

  • Tarascou, I., Barathieu, K., André, Y., Pianet, I., Dufourc, E. J., and Fouquet, E., An improved synthesis of procyanidin dimers: regio- and stereocontrol of the interflavan bond. Eur. J. Org. Chem., 23, 5367–5377 (2006).

    Article  Google Scholar 

  • Wakabayashi, G., Gelfand, J. A., Jung, W. K., Connolly, R. J., Burke, J. F., and Dinarello, C. A., Staphylococcus epidermidis induces complement activation, tumor necrosis factor and interleukin-1, a shock-like state and tissue injury in rabbits without endotoxemia. Comparison to Escherichia coli. J. Clin. Invest., 87, 1925–1935 (1991).

    Article  PubMed  CAS  Google Scholar 

  • Wang, P. and Chaudry, I. H., Mechanism of hepatocellular dysfunction during hyperdynamic sepsis. Am. J. Physiol., 270, R927R–938 (1996).

    Google Scholar 

  • Watson, W. H., Zhao, Y., and Chawla, R. K., S-adenosylmethionine attenuates the lipopolysaccharide-induced expression of the gene for tumour necrosis factor alpha. Biochem. J., 342, 21–25 (1999).

    Article  PubMed  CAS  Google Scholar 

  • Yan, J. J., Jung, J. S., Lee, J. E., Lee, J., Huh, S. O., Kim, H. S., Jung, K. C., Cho, J. Y., Nam, J. S., Suh, H. W., Kim, Y. H., and Song, D. K., Therapeutic effects of lysophosphatidylcholine in experimental sepsis. Nat. Med., 10, 161–167 (2004).

    Article  PubMed  CAS  Google Scholar 

  • Zhang, C. Z., Xu, X. Z., and Li, C., Fructosides from Cynomorium songaricum. Phytochemistry, 41, 975–976 (1996).

    Article  CAS  Google Scholar 

  • Zhang, H., Peterson, J. W., Niesel, D. W., and Klimpel, G. R., Bacterial lipoprotein and lipopolysaccharide act synergistically to induce lethal shock and proinflammatory cytokine production. J. Immunol., 159, 4868–4878 (1997).

    PubMed  CAS  Google Scholar 

  • Zheng, M. S., Lee, Y. K., Li, Y., Hwangbo, K., Lee, C. S., Kim, J. R., Lee, S. K., Chang, H. W., and Son, J. K., Inhibition of DNA topoisomerases I and II and cytotoxicity of compounds from Ulmus davidiana var. japonica. Arch. Pharm. Res., 33, 1307–1315 (2010a).

    Article  PubMed  CAS  Google Scholar 

  • Zheng, M. S., Yang, J. H., Li, Y., Li, X., Chang, H. W., and Son, J. K., Anti-inflammatory activity of constituents isolated from Ulmus davidiana var. japonica. Biomol. Ther., 18, 321–328 (2010b).

    CAS  Google Scholar 

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Authors and Affiliations

  1. College of Pharmacy, Yeungnam University, Gyongsan, 712-749, Korea

    Ming Shan Zheng, Ying Li, Yeun-Kyung Lee, Hyun-Wook Chang & Jong-Keun Son

  2. College of Pharmacy, Yanbian University, Yanji, 133000, China

    Ming Shan Zheng & Gao Li

  3. Korea Institute of Oriental Medicine, Daejeon, 305-811, Korea

    Chang-Seob Seo

  4. Department of Pharmacology, Hallym University College of Medicine, Institute of Natural Medicine, Chunchon, 200-702, Korea

    Jun-Sub Jung & Dong-Keun Song

  5. Departments of Anesthesiology and Pain Medicine, Chonnam National University Medical School, Gwangju, 501-746, Korea

    Hong-Beom Bae & Sang-Hyun Kwak

  6. Department of Biochemistry and Molecular Biology, College of Medicine, Yeungnam University, Daegu, 705-717, Korea

    Jae-Ryong Kim

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  1. Ming Shan Zheng
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Correspondence to Jae-Ryong Kim or Jong-Keun Son.

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Zheng, M.S., Li, G., Li, Y. et al. Protective constituents against sepsis in mice from the root barks of Ulmus davidiana var. japonica . Arch. Pharm. Res. 34, 1443–1450 (2011). https://doi.org/10.1007/s12272-011-0905-6

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  • DOI: https://doi.org/10.1007/s12272-011-0905-6

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