C-7 oxygenated coumarins from the fruits of Micromelum minutum
- 234 Downloads
A new 7-oxygenated coumarin, 7-demethylmurralonginol isovalerate (1), and a new natural product, murralonginol (2), together with seven known 7-oxygenated coumarins, murralonginol isovalerate (3), murralongin (4), micromelin (5), scopoletin (6), microminutin (7), murrangatin (8), and minumicrolin (9), were isolated from the fruits of Micromelum minutum. The structures of these compounds were established on the basis of their 1D and 2D NMR spectroscopic data. Among these isolates, compounds 2 and 4–9 exhibited cytotoxicity against cholangiocarcinoma cell line, KKU-100.
Key wordsMicromelum minutum Rutaceae Coumarin Cytotoxicity Cholangiocarcinoma
Unable to display preview. Download preview PDF.
- Collins, L. and Franzblau, S. G., Microplate alamar blue assay versus BACTEC 460 system for high-throughput screening of compounds against Mycobacterium tuberculosis and Mycobacterium avium. Antimicrob. Agents Chemother., 4, 1004–1009 (1997).Google Scholar
- Imai, F., Kinoshita, T., Itai, A., and Sankawa, U., Acidcatalyzed rearrangement of an epoxy coumarin phebalosin the revised structure of murrlongin. Chem. Pharm. Bull., 34, 3978–3981 (1986).Google Scholar
- Ito, C., Furukawa, H., Ishii, H., Ishikawa, T., and Haginiwa, J., The chemical composition of Murraya paniculata. The structure of five new coumarins and one new alkaloid and the stereochemistry of murrangatin and related coumarins. J. Chem. Soc. Perkin Trans. 1, 2047–2055 (1990).CrossRefGoogle Scholar
- Pongboonrod, S., Maitet Muang Thai. Kasembunakij Press, Bangkok, pp. 624, (1958).Google Scholar
- Smitinand, T., Thai Plant Names. Revised Edition, Prachachon Co. Limited, Bangkok, pp. 357, (2001).Google Scholar