Archives of Pharmacal Research

, Volume 34, Issue 4, pp 527–531 | Cite as

C-7 oxygenated coumarins from the fruits of Micromelum minutum

  • Ratsami Lekphrom
  • Somdej KanokmedhakulEmail author
  • Veerapol Kukongviriyapan
  • Kwanjai Kanokmedhakul
Research Articles Drug Design and Discovery


A new 7-oxygenated coumarin, 7-demethylmurralonginol isovalerate (1), and a new natural product, murralonginol (2), together with seven known 7-oxygenated coumarins, murralonginol isovalerate (3), murralongin (4), micromelin (5), scopoletin (6), microminutin (7), murrangatin (8), and minumicrolin (9), were isolated from the fruits of Micromelum minutum. The structures of these compounds were established on the basis of their 1D and 2D NMR spectroscopic data. Among these isolates, compounds 2 and 49 exhibited cytotoxicity against cholangiocarcinoma cell line, KKU-100.

Key words

Micromelum minutum Rutaceae Coumarin Cytotoxicity Cholangiocarcinoma 


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Copyright information

© The Pharmaceutical Society of Korea and Springer Netherlands 2011

Authors and Affiliations

  • Ratsami Lekphrom
    • 1
  • Somdej Kanokmedhakul
    • 1
    Email author
  • Veerapol Kukongviriyapan
    • 2
  • Kwanjai Kanokmedhakul
    • 1
  1. 1.Natural Products Research Unit, Department of Chemistry, and Center for Innovation in Chemistry, Faculty of ScienceKhon Kaen UniversityKhon KaenThailand
  2. 2.Department of Pharmacology, Faculty of MedicineKhon Kaen UniversityKhon KaenThailand

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