Archives of Pharmacal Research

, Volume 34, Issue 3, pp 437–442 | Cite as

Chalcones isolated from Angelica keiskei and their inhibition of IL-6 production in TNF-α-stimulated MG-63 cell

  • Ji Eun Shin
  • Eun Jin Choi
  • Qinglong Jin
  • Hong-Guang Jin
  • Eun-Rhan WooEmail author
Research Articles Drug Discovery and Development


Six chalcone compounds, 2′,4′,4-trihydroxy-3′-[2-hydroxy-7-methyl-3-methylene-6-octaenyl]chalcone (1), 2′,4′,4-trihydroxy-3′-geranylchalcone (2), 2′,4′,4-trihydroxy-3′-[6-hydroxy-3,7-dimethyl-2,7-octadienyl]chalcone (3), 2′,4-dihydroxy-4′-methoxy-3′-[2-hydroperoxy-3-methyl-3-butenyl]chalcone (4), 2′,4-dihydroxy-4′-methoxy-3′-geranylchalcone (5), and 2′,4-dihydroxy-4′-methoxy-3′-[3-methyl-3-butenyl]chalcone (6) were isolated from the leaves of Angelica keiskei K (Umbelliferae). The structure of each isolated compound was determined using spectroscopic methods. Among the isolates, compounds 13 appeared to have potent inhibitory activity of IL-6 production in TNF-α-stimulated MG-63 cell, while compounds 46 did not. The distinct structural difference between compounds 13 and 46 was the presence of C-4′ hydroxyl group in the chalcone moiety. Our results imply that the inhibitory activity of IL-6 production in TNF-α-stimulated MG-63 cell may be affected by the presence of C-4′ hydroxyl group in the chalcone moiety.

Key words

Angelica keiskei koidzumi Umbelliferae C-geranylated chalcone IL-6 inhibitory activity 


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Copyright information

© The Pharmaceutical Society of Korea and Springer Netherlands 2011

Authors and Affiliations

  • Ji Eun Shin
    • 1
  • Eun Jin Choi
    • 1
  • Qinglong Jin
    • 1
  • Hong-Guang Jin
    • 1
  • Eun-Rhan Woo
    • 1
    Email author
  1. 1.College of PharmacyChosun UniversityGwangjuKorea

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