Abstract
A new phenolic amide, tribulusimide D (4-hydroxy-N-[3-(4-hydroxy-3-methoxyphenyl)-1-oxo-2-propen-1-yl]-3-methoxybenzamide) (1), together with a known phenolic amide, terrestriamide ((E)-3-(4-hydroxy-3-methoxyphenyl)-N-[2-(4-hydroxyphenyl)-2-oxoethyl]-prop-2-enamide) (2) and a flavonol glycoside, quercetin-3-O-β-d-glucopyranosyl-(1→6)-β-d-glucopyranoside (3) were isolated from the H2O extract of Tribuli Fructus. Compounds 1 and 3 showed significant hepatoprotective activities, with EC50 values of 13.46 ± 0.2 and 7.06 ± 0.7 μM, respectively, against tacrine-induced cytotoxicity in HepG2 cells.
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Byun, E., Jeong, GS., An, RB. et al. Tribuli fructus constituents protect against tacrine-induced cytotoxicity in HepG2 cells. Arch. Pharm. Res. 33, 67–70 (2010). https://doi.org/10.1007/s12272-010-2226-6
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DOI: https://doi.org/10.1007/s12272-010-2226-6