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Cytotoxic 10-(indol-3-yl)-[13]cytochalasans from the fungus Chaetomium elatum ChE01

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Abstract

Nine 10-(indol-3-yl)-[13]cytochalasans such as a new chaetoglobosin V (1); two new natural products, prochaetoglobosin III (2) and prochaetoglobosin IIIed (3); six known chaetoglobosins B-D (4–6), F (7), and G (8) and isochaetoglobosin D (9) in addition to two known sterols, 24(R)-5α,8α-epidioxyergosta-6–22-diene-3β-ol (10) and ergosterol (11), were isolated from the fungus Chaetomium elatum ChE01. The structures of these compounds were elucidated by spectroscopic methods. Compounds 1–9 showed cytotoxicity against the human breast cancer (IC50 2.54–21.29 μM) and cholangiocarcinoma cell lines (IC50 3.41–86.95 μM).

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Authors and Affiliations

  1. Natural Products Research Unit, Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, 40002, Thailand

    Santi Thohinung, Somdej Kanokmedhakul & Kwanjai Kanokmedhakul

  2. Department of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand

    Veerapol Kukongviriyapan & Ornanong Tusskorn

  3. Plant Pest Management, Faculty of Agricultural Technology, King Mongkut’s Institute of Technology Ladkrabang, Ladkrabang, Bangkok, 10520, Thailand

    Kasem Soytong

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  1. Santi Thohinung
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  2. Somdej Kanokmedhakul
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  3. Kwanjai Kanokmedhakul
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  4. Veerapol Kukongviriyapan
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  5. Ornanong Tusskorn
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  6. Kasem Soytong
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Correspondence to Somdej Kanokmedhakul.

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Thohinung, S., Kanokmedhakul, S., Kanokmedhakul, K. et al. Cytotoxic 10-(indol-3-yl)-[13]cytochalasans from the fungus Chaetomium elatum ChE01. Arch. Pharm. Res. 33, 1135–1141 (2010). https://doi.org/10.1007/s12272-010-0801-5

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  • DOI: https://doi.org/10.1007/s12272-010-0801-5

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