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Mucoadhesive and floating chitosan-coated alginate beads for the controlled gastric release of amoxicillin

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Abstract

This work focused on the development of mucoadhesive and floating chitosan-coated alginate beads as a gastroretensive delivery vehicle for amoxicillin, towards the effective eradication of Helicobacter pylori, a major causative agent of peptic ulcers. Alginate was used as the core bead core polymer and chitosan as the mucoadhesive polymer coating. Amoxicillin-loaded alginate beads coated with 0.5% (w/v) chitosan (ALG/0.5%CHI) exhibited excellent floating ability, high encapsulation efficiency, high drug loading capacity, and a strong in vitro mucoadhesion to the gastric mucosal layer. In vitro, amoxicillin was released faster in simulated gastric fluid (pH 1.2, HCl) than in simulated intestinal fluid (phosphate buffer, pH 7.4). ALG/0.5%CHI could be prepared with a > 90% drug encapsulation efficiency and exhibited more than 90% muco-adhesiveness, 100% floating ability, and achieved sustained release of amoxicillin for over six hours in SGF.

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Authors and Affiliations

  1. Program of Petrochemistry and Polymer Science, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand

    Teerawat Sahasathian

  2. Department of Biology, Faculty of Science, Srinakarinwirot University, Bangkok, 10300, Thailand

    Nalena Praphairaksit

  3. Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand

    Nongnuj Muangsin

Authors
  1. Teerawat Sahasathian
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  2. Nalena Praphairaksit
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  3. Nongnuj Muangsin
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Correspondence to Nongnuj Muangsin.

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Sahasathian, T., Praphairaksit, N. & Muangsin, N. Mucoadhesive and floating chitosan-coated alginate beads for the controlled gastric release of amoxicillin. Arch. Pharm. Res. 33, 889–899 (2010). https://doi.org/10.1007/s12272-010-0612-8

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  • DOI: https://doi.org/10.1007/s12272-010-0612-8

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