Synthesis and preliminary antibacterial evaluation of 2-butyl succinate-based hydroxamate derivatives containing isoxazole rings
- First Online:
- Cite this article as:
- Zhang, D., Jia, J., Meng, L. et al. Arch. Pharm. Res. (2010) 33: 831. doi:10.1007/s12272-010-0605-7
Two series of novel 2-butyl succinate-based Hydroxamate derivatives containing isoxazole rings were synthesized, characterized and evaluated for antibacterial activity. The synthesized compounds were found to exhibit weak to moderate inhibitory activity against Staphytlococcusaureu and Klebsiellar pneumonia in vitro. All the compounds synthesized were found to be more effective against Klebsiellar pneumonia compared to Staphytlococcus aureu.
Key words2-Butyl succinate-based hydroxamate derivatives Isoxazole Synthesis Antibacterial activity
Unable to display preview. Download preview PDF.