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Two new hetero-spirocyclic γ-lactam derivatives from marine sediment-derived fungus Aspergillus sydowi D2–6

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Abstract

Two new hetero-spirocyclic γ-lactams, azaspirofurans A (1) and B (2), had been isolated from a marine sediment-derived fungus Aspergillus sydowi D2–6. Their structures were determined by the chemical evidence and spectral analyses. Compound 1 exhibited cytotoxicity against A549 cell line with the IC50 value of 10 μM by MTT method.

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Authors and Affiliations

  1. Key Laboratory of Marine Drugs, Chinese Ministry of Education; Institute of Marine Drugs and Food, Ocean University of China, Qingdao, 266003, China

    Hong Ren, Rui Liu, Li Chen, Tianjiao Zhu & Qian Qun Gu

  2. College of Chemical and Environmental Engineering, Beijing Key Laboratory of Plant Resource Research and Development, Beijing Technology and Business University, Beijing, 100048, China

    Hong Ren

Authors
  1. Hong Ren
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  2. Rui Liu
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  3. Li Chen
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  4. Tianjiao Zhu
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  5. Wei Ming Zhu
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  6. Qian Qun Gu
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Corresponding author

Correspondence to Qian Qun Gu.

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These authors contributed equally to this work.

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Ren, H., Liu, R., Chen, L. et al. Two new hetero-spirocyclic γ-lactam derivatives from marine sediment-derived fungus Aspergillus sydowi D2–6. Arch. Pharm. Res. 33, 499–502 (2010). https://doi.org/10.1007/s12272-010-0401-4

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  • DOI: https://doi.org/10.1007/s12272-010-0401-4

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