Skip to main content
Log in

An anti-influenza component of the bark of Alnus japonica

  • Published:
Archives of Pharmacal Research Aims and scope Submit manuscript

Abstract

This study to identify anti-influenza components of the bark of Alnus japonica resulted in the isolation of four lupane-type triterpenes (14) and one steroid (5). Their structures were characterized on the basis of physicochemical properties, NMR evidence, and ESI-MS data compared with reported data in the literature. Betulinic aldehyde (3) exhibited a particularly strong anti-influenza effect against KBNP-0028 relative to a positive control.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Chang, I. M, Yun, H. S., Yamasaki, K., Revision of 13C NMR Assignments of β-sitosterol and β-sitosteryl-3-O-β-D-glucopyranoside from Platago asiatica Seed. Kor. J. Pharmacog., 12, 12–14 (1981).

    CAS  Google Scholar 

  • Fulton, F. and Armitage, P., Surviving tissue suspensions for influenza virus titration. J. Hyg., 49, 247–262 (1951).

    Article  CAS  Google Scholar 

  • Hiroya, K., Takahashi, T., Miura, N., Naganuma, A., and Sakamoto, T., Synthesis of betulin derivatives and their protective effects against the cytotoxicity of cadmium. Bioorg. Med. Chem., 10, 3229–3236 (2002).

    Article  CAS  PubMed  Google Scholar 

  • Kim, H. J., Yeom, S. H., Kim, M. K., Shim J. G., Paek, I. N., and Lee, M. W., Nitric oxide and prostaglandin E2 synthesis inhibitory activities of diarylheptanoids from the barks of Alnus japonica Steudel. Arch. Pharm. Res., 28, 177–179 (2005).

    Article  PubMed  Google Scholar 

  • Kuroyanagi, M., Shimomae, M., Nagashima, Y., Muto, N., Okuda, T., Kawahara, N., Nakane, T., and Sano, T., New diarylheptanoids from Alnus japonica and their antioxidative activity. Chem. Pharm. Bull., 53, 1519–1523 (2005).

    Article  CAS  PubMed  Google Scholar 

  • Kwon, H. J., Cho, S. H., Ahn, Y. J., Kim, J. H., Yoo, H. S., and Kim, S. J., Characterization of a Chicken Embryo-Adapted H9N2 Subtype Avian Influenza Virus. The Open Vet. Sci. J., 3, 9–16 (2009).

    Article  CAS  Google Scholar 

  • Lee, M. W., Tanaka, T., Nonaka, G. I., and Nishioka, I., Tannins and related compounds. Part 115. Dimeric ellagitannins from Alnus japonica. Phytochemistry, 31, 2835–2839 (1992).

    Article  CAS  Google Scholar 

  • Lee, S. J., Korea folk medicine. Seoul National University Publishing Center Press, Seoul, Korea, pp. 40, (1996).

    Google Scholar 

  • Mosmann, T., Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J. Immunol. Methods, 65, 55–63 (1983).

    Article  CAS  PubMed  Google Scholar 

  • Ra, J. C., Kwon, H. J., Kim, B. G., and You, S. H., Anti-influenza viral composition containing bark or stem extract of Alnus japonica. WO 2009075488 A2 20090618 (2009).

  • Sholichin, M., Yamasaki, K., Kasai, R., and Tanaka, O., 13C NMR of Lupane-type triterpenes, lupeol, betulin and betulinic acid. Chem. Pharm. Bull., 28, 1006–1008 (1980).

    CAS  Google Scholar 

  • Wada, H., Tachibana, H., Fuchino, H., and Tanaka, N., Three new diarylheptanoid glycosides from Alnus japonica. Chem. Pharm. Bull., 46, 1054–1055 (1998).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Young Ho Kim.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Tung, N.H., Kwon, HJ., Kim, JH. et al. An anti-influenza component of the bark of Alnus japonica . Arch. Pharm. Res. 33, 363–367 (2010). https://doi.org/10.1007/s12272-010-0303-5

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12272-010-0303-5

Key words

Navigation