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Antinociceptive profiles and mechanisms of orally administered vanillin in the mice

Abstract

In the present study, the antinociceptive profiles of vanillin were examined in ICR mice. Vanillin administered orally (from 1 to 10 mg/kg) showed an antinociceptive effect in a dose-dependent manner as measured in the acetic acid-induced writhing test. Duration of antinociceptive action of vanillin maintained at least for 30 min. But, the cumulative response time of nociceptive behaviors induced by a subcutaneous (s.c.) formalin injection, intrathecal (i.t.) substance P (0.7 µg) or glutamate (20 µg) injection was not affected by vanillin. Intraperitoneal (i.p.) pretreatment with yohimbine (α2-adrenergic receptor antagonist) or naloxone (opioid receptor antagonist) attenuated antinociceptive effect induced by vanillin in the writhing test. However, phentolamine (α1-adrenergic receptor antagonist) or methysergide (5-HT serotonergic receptor antagonist) did not affect antinociception induced by vanillin in the writhing test. Our results suggest that vanillin exerts a selective antinociceptive property in the acetic acidinduced visceral inflammatory pain model. Furthermore, this antinociceptive effect of vanillin may be mediated by α2-adrenergic and opioid receptors, but not α1-adrenergic and serotonergic receptors.

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Correspondence to Hong-Won Suh.

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Park, SH., Sim, YB., Choi, SM. et al. Antinociceptive profiles and mechanisms of orally administered vanillin in the mice. Arch. Pharm. Res. 32, 1643 (2009). https://doi.org/10.1007/s12272-009-2119-8

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  • DOI: https://doi.org/10.1007/s12272-009-2119-8

Key words

  • Vanillin
  • Antinociception
  • Inflammatory pain
  • α2 adrenoceptor
  • Opioid receptor