Abstract
A new ent-kaurane type diterpenoid glycoside, 17-O-β-D-glucopyranosyl-16α-ent-kauran-19-oic acid (1), together with 17-hydroxy-16α-ent-kauran-19-oic acid (2), 16α,17-dihydroxyl-ent-kauran-19-oic acid (3), and 16α-hydroxy-17-acetoxy-ent-kauran-19-oic acid (4) were isolated from the aerial parts of Inula japonica Thunb. The structure of 1 was determined mainly by use of 1D and 2D NMR spectroscopic techniques including HSQC, 1H-1H COSY, HMBC, and NOESY. In addition, 4 exhibited significant inhibitory activity on NO production in LPS-stimulated RAW264.7 cells with IC50 value of 14.3 µg/mL.
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Qin, J.J., Zhu, J.X., Zhang, W.D. et al. A new ent-kaurane type diterpenoid glycoside from Inula japonica Thunb.. Arch. Pharm. Res. 32, 1369–1372 (2009). https://doi.org/10.1007/s12272-009-2004-5
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DOI: https://doi.org/10.1007/s12272-009-2004-5