Amino and nitro derivatives of 5,7-dimethoxyflavone from Kaempferia parviflora and cytotoxicity against KB cell line

Abstract

Structural modification of 5,7-dimethoxyflavone isolated from Kaempferia parviflora furnished two nitro and seven amino derivatives. Among these, six new (3, 5–6, 8–10) and three known (2, 4, 7) flavonoid derivatives were synthesized. All compounds were evaluated for cytotoxicity against KB cell line using colorimetric method. Compounds 6 and 8 exhibited strong cytotoxicity with IC50 values of 6.80 and 5.84 µg/mL, respectively.

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Correspondence to Chavi Yenjai.

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Wanich, S., Yenjai, C. Amino and nitro derivatives of 5,7-dimethoxyflavone from Kaempferia parviflora and cytotoxicity against KB cell line. Arch. Pharm. Res. 32, 1185–1189 (2009). https://doi.org/10.1007/s12272-009-1901-y

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Key words

  • Kaempferia parviflora
  • Aminoflavonoids
  • Nitroflavonoids
  • Cytotoxicity
  • KB cells