Abstract
A new triterpenoid, bruceajavanin C (1), together with bruceosides A and B (2 and 3), bruceines D and E (4 and 5), yadanziosides A and G (6 and 7), (20R)-O-(3)-α-L-arabinopyranosylpregn-5-ene-3β,20-diol (8), and α-D-glucopyranoside, (3β, 20R)-3-hydroxypregn-5-en-20-yl (9) were isolated from the aerial parts of Brucea javanica. The structure of 1 was elucidated on the basis of 2D-NMR spectroscopic analysis. In addition, compounds 1, 3, 4, 5, and 6 exhibited mild inhibitory effect on NO production in LPS-stimulated RAW264.7 cells.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Denizot, F. and Lang, R., Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. J. Immunol. Methods, 89, 271–277 (1986).
Fukamiya, N., Okano, M., and Miyamoto, M., Antitumor agents, 127. 1 bruceoside C, a new cytotoxic quassinoid glucoside, and related compounds from Brucea javanica. J. Nat. Prod., 55, 468–475 (1992).
Jin, H. Z., Hwang, B. Y., Kim, H. S., Lee, J. H., Kim, Y. H., and Lee, J. J., Antiinflammatory constituents of Celastrus orbiculatus inhibits the NF-kB activation and NO production. J. Nat. Prod., 65, 89–91 (2002).
Lau, F. Y., Chui, C. H., and Gambari, R., Antiproliferative and apoptosis-inducing activity of Brucea javanica extract on human carcinoma cells. Int. J. Mol. Med., 16, 1157–1162 (2005).
Li, X., Wu, L. J., and Konda, Y., Bruceines D, E and H. J. Heterocyclic Chem., 26, 493–501 (1989).
Kamperdick, C., Sung, T. V., and Thuy, T. T., (20R)-O-(3)-α-L-arabinopyranosyl-pregn-5-ene-3β, 20-diol from Brucea javanica. Phytochem., 38, 699–701 (1995).
Kitagawa, I., Mahmud, T., and Simanjuntak, P., Indonesian medicinal plants. VIII. Chemical structures of three new triterpenoids, bruceajavanin A, dihydrobruceajavanin A, and bruceajavanin B, and a new alkaloidal glycoside, bruceacanthinoside, from the stems of Brucea javanica. Chem. Pharm. Bull., 42, 1416–1421(1994).
Ohnishi, S., Fukamiya, N., and Okano, M., Bruceosides D, E, and F, three new cytotoxic quassinoid glucosides from Brucea javanica. J. Nat. Prod., 58, 1032–1038 (1995).
Schmidt, H. H. H. W. and Kelm M., Determination of nitrite and nitrate by the Griess reaction. In: Methods in nitric oxide research. London, John Wiley & Sons Ltd., Chapter 33, pp. 491–497, (1996).
Shen, J. G., Zhang, Z. K., and Wu, Z. J., Antiphytoviral activity of bruceine D from Brucea javanica seeds. Pest Manage Sci., 64, 191–196 (2008).
Thompson, M. J., Svoboda, J. A., and Lusby, W. R., Biosynthesis of a C21 steroid conjugate in an insect. J. Biol. Chem., 260, 15410–15412 (1985).
Xue, S. Y., Chen, S. W., and Wu, J. S., Antigastric ulcerative actions emulsive granules of seed oil of Brucea javanica. Shenyang Yaoke Daxue Xuebao, 13, 13–17 (1996).
Author information
Authors and Affiliations
Corresponding authors
Rights and permissions
About this article
Cite this article
Liu, J.H., Qin, J.J., Jin, H.Z. et al. A new triterpenoid from Brucea javanica . Arch. Pharm. Res. 32, 661–666 (2009). https://doi.org/10.1007/s12272-009-1503-8
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12272-009-1503-8