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An oxepinoflavone from Artocarpus elasticus with cytotoxic activity against P-388 cells

  • Iqbal Musthapa
  • Lia D. Juliawaty
  • Yana M. Syah
  • Euis H. Hakim
  • Jalifah Latip
  • Emilio L. Ghisalberti
Research Articles Drug Discovery and Development

Abstract

A new oxepinoflavone, artoindonesianin E1 (1), was isolated from the wood of Artocarpus elasticus, along with four known prenylated flavones: artocarpin (2), cycloartocarpin (3), cudraflavones A (4) and C (5). The structure of the new compound was identified by spectroscopic methods. Upon cytotoxic evaluation against murine leukemia P-388 cells, the new compound showed IC50 5.0 μg/mL.

Key words

Artocarpus elasticus Flavonoids Oxepinoflavone Artoindonesianin E1 Cytotoxicity P-388 cells 

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Copyright information

© The Pharmaceutical Society of Korea 2009

Authors and Affiliations

  • Iqbal Musthapa
    • 1
  • Lia D. Juliawaty
    • 1
  • Yana M. Syah
    • 1
  • Euis H. Hakim
    • 1
  • Jalifah Latip
    • 2
  • Emilio L. Ghisalberti
    • 3
  1. 1.Institut Teknologi BandungNatural Products Research Group, Faculty of Mathematics and Natural SciencesBandungIndonesia
  2. 2.School of Chemistry and Food Technology, Faculty of Science and TechnologyNational University of MalaysiaBangiMalaysia
  3. 3.Chemistry, School of Biomedical, Biomolecular and Chemical SciencesUniversity of Western AustraliaCrawleyAustralia

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