Abstract
Inhibition of acyl CoA:diacylglycerol acyltransferase (DGAT) is proposed to be a drug target for the treatment of obesity and type 2 diabetes. Bioassay-guided fractionation of the CH2Cl2-soluble extract of the stem bark of Erythrina senegalensis, using an in vitro DGAT enzyme assay, resulted in the isolation of eight known prenylflavonoids, 8-prenylleutone (1), auriculatin (2), erysenegalensein O (3), erysenegalensein D (4), erysenegalensein N (5), derrone (6), alpinumisoflavone (7), and 6,8-diprenylgenistein (8). Compounds 1, 2–4, 6, and 8 inhibited DGAT activity, with IC50 values ranging from 1.1 ± 0.3 to 15.1 ± 1.1 μg/mL. On the basis of the data obtained, we propose isoflavonoids with isoprenyl groups as a novel class of DGAT inhibitors.
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An erratum to this article can be found online at http://dx.doi.org/10.1007/s12272-009-1236-8
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Oh, W.K., Lee, C.H., Seo, J.H. et al. Diacylglycerol acyltransferase-inhibitory compounds from Erythrina senegalensis . Arch. Pharm. Res. 32, 43–47 (2009). https://doi.org/10.1007/s12272-009-1116-2
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DOI: https://doi.org/10.1007/s12272-009-1116-2