trans-resveratrol relaxes the corpus cavernosum ex vivo and enhances testosterone levels and sperm quality in vivo
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We examined the effects of trans-resveratrol on male reproductive functions; ex-vivo penile erection and in-vivo sperm counts and quality. For the ex-vivo study, the relaxation effects of resveratrol on isolated New Zealand white rabbit corpus cavernosum, precontracted by phenylephrine (5×10−5 M) were measured. The in-vivo study measured reproductive organ weights, blood testosterone levels, testicular histopathology, sperm counts, as well as the epididymal sperm motility and deformity of male ICR mice given an oral dose of resveratrol (50 mg/kg) for 28 days. Resveratrol elicited a concentration-dependent relaxing effect on corpus cavernosum, leading to a median effective concentration (EC50) of 0.29 mg/mL. Repeated treatment with resveratrol (50 mg/kg) did not cause an increase in body weight, reproductive organ weight or testicular microscopic findings; however, resveratrol did elicit an increase in blood testosterone concentration, testicular sperm counts and epididymal sperm motility by 51.6%, 15.8% and 23.3%, respectively, without influence on sperm deformity. In conclusion, we propose that resveratrol has a positive effect on male reproductive function by triggering a penile erection, as well as enhancing blood testosterone levels, testicular sperm counts, and epididymal sperm motility.
Key wordsResveratrol Corpus cavernosum relaxation Testosterone Sperm counts and motility
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- Chen, C. K. and Pace-Asciak, C. R., Vasorelaxing activity of resveratrol and quercetin in isolated rat aorta. Gen. Pharmac., 27, 363–366 (1996).Google Scholar
- Fouad, R., Vivien, K., and Ronald, S., Male sexual function and its disorders: physiology, pathophysiology, clinical investigation, and treatment. Endocr. Rev., 22, 342–388 (1993).Google Scholar
- Jeon, J. H., Shin, S., Park, D., Jang, J. Y., Choi, B., Kang, J.-K., Hwang, S.-Y., and Kim, J.-C., Kim, B.-Y., Kim, M. R., and Kim, Y.-B., Fermentation filtrates of Rubus coreanus relax the corpus cavernosum and increase the sperm count and motility. J. Med. Food in press (2007).Google Scholar
- Jouannet, P., Wang, C., Eustache, F., Kold-Jensen, T., and Auger, J., Semen quality and male reproductive health: the controversy about human sperm concentration decline. Acta Pathol. Microbiol. Immunol. Scand., 109, 333–344 (2001).Google Scholar
- Sinclair, S., Male fertility: nutritional and environmental considerations. Altern. Med. Rev., 5, 28–38 (2005).Google Scholar
- Wallerath, T., Poleo, D., Li, H., and Forstermann, U., Red wine increase the expression of human endothelial nitric oxide synthase: a mechanism that may contribute to its beneficial cardiovascular effects. J. Am. College Cardiol., 41, 479–478 (2003).Google Scholar