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Anti-angiogenic, anti-inflammatory and anti-nociceptive activities of vanillyl alcohol

Archives of Pharmacal Research volume 31, pages 1275–1279 (2008)Cite this article

Abstract

Vanillyl alcohol displayed a significant inhibition in the chick chorioallantoic membrane (CAM) angiogenesis. Vanillyl alcohol was also shown to contain anti-inflammatory activity using acetic acid-induced permeability and carrageenan-induced air pouch models in mice. Anti-nociceptive activity of vanillyl alcohol was also assessed using acetic acid-induced writhing test in mice. Taken together, vanillyl alcohol possesses anti-angiogenic, anti-inflammatory, and anti-nociceptive activities, which may be partly responsible for pharmacological efficacies of several folkloric medicines containing vanillyl alcohol.

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Affiliations

  1. Division of Life Sciences and Research Institute of Life Sciences, Kangwon National University, Chuncheon, 200-701, Korea

    Chang-Jin Lim

  2. College of Pharmacy, Sookmyung Women’s University, Seoul, 140-742, Korea

    Hyun-Joo Jung, Yun Seon Song, Chang-Jin Lim & Eun-Hee Park

Authors
  1. Hyun-Joo Jung
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  2. Yun Seon Song
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  3. Chang-Jin Lim
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  4. Eun-Hee Park
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Correspondence to Eun-Hee Park.

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Jung, HJ., Song, Y.S., Lim, CJ. et al. Anti-angiogenic, anti-inflammatory and anti-nociceptive activities of vanillyl alcohol. Arch. Pharm. Res. 31, 1275–1279 (2008). https://doi.org/10.1007/s12272-001-2106-1

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  • DOI: https://doi.org/10.1007/s12272-001-2106-1

Key words

  • Vanillyl alcohol
  • Anti-inflammatory
  • Anti-angiogenic
  • Anti-nociceptive