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Antiallergic effect of the root of Paeonia lactiflora and its constituents paeoniflorin and paeonol

Archives of Pharmacal Research volume 31, pages 445–450 (2008)Cite this article

Abstract

The root of Paeonia lactiflora PALL (PL, Family Paeoniaceae) has been used frequently as an antipyretic and anti-inflammatory agent in traditional medicines of Korea, China and Japan. To evaluate antiallergic effect of PL, we isolated its main constituents, paeoniflorin and paeonol, and evaluated in vivo their inhibitory effects against passive cutaenous anaphylaxis (PCA) reaction induced by IgE-antigen complex and scratching behaviors induced by compound 48/80. PL, paeoniflorin and paeonol potently inhibited PCA reaction and scratching behaviors in mice. Paeoniflorin exhibited the most potent inhibition against scratching behaviors and the acetic acid-induced writhing syndrome in mice. Paeonol most potently inhibited PCA reaction and mast cells degranulation. These findings suggest that PL can improve IgE-induced anaphylaxis and scratching behaviors, and may be due to the effect of its constituents, paeoniflorin and paeonol.

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References

  • Akagi, M., Mio, M., Miyoshi, K., and Tasaka, K., Antiallergic effects of terfenadine on immediate type hypersensitivity reactions. Immunopharmacol. Immunotoxicol., 9, 257–224 (1987).

    PubMed  Article  CAS  Google Scholar 

  • Bielory, L., Complementary and alternative interventions in asthma, allergy, and immunology. Ann. Allergy Asthma Immunol., 93(2 Suppl 1), S45–S54 (2004)

    PubMed  Article  Google Scholar 

  • Chand, N., Pillar, J., Diamantis, W., Perhach Jr, J. L., and Sofia, R. D., Inhibition of calcium ionopore (A23187)-stimulated histamine release from rat peritoneal mast cells by azelastine. Eur. J. Pharmacol., 96, 227–233 (1983).

    PubMed  Article  CAS  Google Scholar 

  • Chen, C. L., Wang, S. D., Zeng, Z. Y., Lin, K. J., Kao, S. T., Tani, T., Yu, C. K., and Wang, J. Y., Serine protease inhibitors nafamostat mesilate and gabexate mesilate attenuate allergen-induced airway inflammation and eosinophilia in a murine model of asthma. J. Allergy Clin. Immunol., 118, 105–112 (2006).

    PubMed  Article  CAS  Google Scholar 

  • Choo, M. K., Park, E. K., Han, M. J., and Kim, D. H., Antiallergic activity of ginseng and its ginsenoside. Planta Med., 69, 518–522 (2003).

    PubMed  Article  CAS  Google Scholar 

  • Chou, T. C., Anti-inflammatory and analgesic effects of paeonol in carrageenan-evoked thermal hyperalgesia. Br. J. Pharmacol., 139, 1146–1152 (2003).

    PubMed  Article  CAS  Google Scholar 

  • Goto, H., Shimada, Y., Akechi, Y., Kohta, K., Hattori, M., and Terasawa, K., Endothelium-dependent vasodilator effect of extract prepared from the roots of Paeonia lactiflora on isolated rat aorta. Planta Med., 62, 436–439 (1996).

    PubMed  Article  CAS  Google Scholar 

  • Hsieh, C. L., Cheng, C. Y., Tsai, T. H., Lin, I. H., Liu, C. H., Chiang, S. Y., Lin, J. G., Lao, C. J., and Tang N. Y., Paeonol reduced cerebral infarction involving the superoxide anion and microglia activation in ischemia-reperfusion injured rats. J. Ethnopharmacol., 106, 208–215 (2006).

    PubMed  Article  CAS  Google Scholar 

  • Heikal, O. A., Akao, T., Takeda, S., and Hattori, M., Pharmacokinetic study of paeonimetabolin I, a major metabolite of paeoniflorin from paeony roots. Biol. Pharm. Bull., 20, 517–521 (1997).

    PubMed  CAS  Google Scholar 

  • Inagaki, N., Nakamura, N., Nagao, M., Kawasaki, H., and Nagai, H., Inhibition of passive cutaneous anaphylaxis-associated scratching behavior by u-opioid rector antagonist in ICR mice. Int. Arch. Allergy Immunol., 123, 65-3682000.

  • Ito, H., Miyazaki, T., On, o M., and Sakurai, H., Antiallergic activities of rabdosiin and its related compounds: chemical and biochemical evaluations. Bioorg. Med. Chem., 6, 1051–1056 (1998).

    PubMed  Article  CAS  Google Scholar 

  • Khan, T., Ahmad, M., Nisar, M., Ahmad, M., Lodhi, M. A., and Choudhary, M. I., Enzyme inhibition and radical scavenging activities of aerial parts of Paeonia emodi Wall (Paeoniaceae). J. Enzyme Inhib. Med. Chem., 20, 245–249 (2005).

    PubMed  Article  CAS  Google Scholar 

  • Kim, S. H., Kim, S. A., Park, M. K., Kim, S. H., Park, Y. D., Na, H. J., Kim, H. M., Shin, M. K., and Ahn, K. S., Paeonol inhibits anaphylactic reaction by regulating histamine and TNF-alpha. Int. Immunopharmacol., 4, 279–287 (2004).

    PubMed  Article  CAS  Google Scholar 

  • Mastuda, H., Morikawa, T., Ueda, K., Managi, H., Yoshikawa, M., Structural requirements of flavonoids for inhibition of antigen-Induced degranulation, TNF-alpha and IL-4 production from RBL-2H3 cells. Bioorg. Med. Chem., 10, 3123–3128 (2002).

    PubMed  Article  CAS  Google Scholar 

  • Mi, X. J., Chen, S. W., Wang, W. J., Wang, R., Zhang, Y. J., Li, W. J., and Li, Y. L., Anxiolytic-like effect of paeonol in mice. Pharmacol. Biochem. Behav., 81, 683–687 (2005).

    PubMed  Article  CAS  Google Scholar 

  • Mitre, E., and Nutman, T.B., Basophils, basophilia and helminth infections. Chem. Immunol. Allergy, 90, 141–156 (2006).

    PubMed  Article  CAS  Google Scholar 

  • Nicoloff, B. J., The cytokine network in psoriasis. Arch. Dermatol., 127, 871–884 (1991).

    Article  Google Scholar 

  • Plaut, M., Pierce, J. H., Whatson, C., Hanley-Hyde, J., Nordan, R. P., and Paul, W. E., Mast cell lines produce lymphokines in response to cross-linkage of Fc epsilon RI or to calcium ionophore. Nature, 339, 64–67 (1989).

    PubMed  Article  CAS  Google Scholar 

  • Bruhns, P., Fremont, S., and Daeron, M., Regulation of allergy by Fc receptors. Curr. Opin. Immunol., 17, 662–669 (2005).

    PubMed  Article  CAS  Google Scholar 

  • Sakuma, S., Higashi, Y., Sato, N., Sasakawa, T., Sengoku, T., Ohkubo, Y., Amaya, T., and Goto, T., Tacrolimus suppressed the production of cytokines involved in atopic dermatitis by direct stimulation of human PBMC system. (Comparison with steroids). Int. Immunopharmacol., 1, 1219–1226 (2001).

    PubMed  Article  CAS  Google Scholar 

  • Schafer-Korting, M., Schmid, M. H., and Korting, H. C., Topical glucocorticoids with improved risk-benefit ratio. Rationale of a new concept. Drug Safety, 14, 375–385 (1996).

    PubMed  CAS  Google Scholar 

  • Simons, F. E., The antiallergic effects of antihistamines (H1-receptor antagonists). J. Allergy Clin. Immunol., 90, 705–715 (1992).

    PubMed  Article  CAS  Google Scholar 

  • Stevens, R. L. and Austen, K. F., Recent advances in the cellular and molecular biology of mast cells. Immunol. Today, 10, 381–386 (1989).

    PubMed  Article  CAS  Google Scholar 

  • Sugimoto, Y., Umakoshi, K., Nojiri, N., and Kamei, C., Effect of histamine H1 receptor antagonists on compound 48/80-induced scratching behavior in mice. Eur. J. Pharmacol., 351, 1–5 (1998).

    PubMed  Article  CAS  Google Scholar 

  • Tsai, T. Y., Wu, S. N., Liu, Y. C., Wu, A. Z., Tsai, Y. C., Inhibitory action of L-type Ca2+ current by paeoniflorin, a major constituent of peony root, in NG108-15 neuronal cells. Eur. J. Pharmacol., 523, 16–24 (2005).

    PubMed  Article  CAS  Google Scholar 

  • Wuthrich, B., Epidemiology of the allergic diseases: are they really on the increase? Int. Arch. Allergy Appl. Immunol., 90(suppl. 1), 3–10 (1989).

    PubMed  Google Scholar 

  • Xiao, L., Wang, Y. Z., Liu, J., Luo, X. T., Ye, Y., and Zhu, X.Z., Effects of paeoniflorin on the cerebral infarction, behavioral and cognitive impairments at the chronic stage of transient middle cerebral artery occlusion in rats. Life Sci., 78, 413–420 (2005).

    PubMed  Article  CAS  Google Scholar 

  • Yang, S. H., Hong, C. Y., and Yu, C. L., Decreased serum IgE level, decreased IFN-gamma and IL-5 but increased IL-10 production, and suppressed cyclooxygenase 2 mRNA expression in patients with perennial allergic rhinitis after treatment with a new mixed formula of Chinese herbs. Int. Immunopharmacol., 1, 1173–1182 (2001).

    PubMed  Article  CAS  Google Scholar 

  • Yang, H. O., Ko, W. K., Kim, J. Y., and Ro, H. S. Paeoniflorin: an antihyperlipidemic agent from Paeonia lactiflora. Fitoterapia, 75, 45–49 (2004).

    PubMed  Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Life and Nanopharmaceutical Sciences and Department of Pharmaceutical Science, Kyung Hee University, Seoul, 130-701, Korea

    Bomi Lee, Yong-Wook Shin, Eun-Ah Bae, San-Jun Han, Joo-Sun Kim, Sam-Sik Kang & Dong-Hyun Kim

  2. Institute of Natural Products, Seoul National University, Seoul, 110-460, Korea

    Joo-Sun Kim & Sam-Sik Kang

Authors
  1. Bomi Lee
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  2. Yong-Wook Shin
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  3. Eun-Ah Bae
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  4. San-Jun Han
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  5. Joo-Sun Kim
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  6. Sam-Sik Kang
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  7. Dong-Hyun Kim
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Correspondence to Dong-Hyun Kim.

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Lee, B., Shin, YW., Bae, EA. et al. Antiallergic effect of the root of Paeonia lactiflora and its constituents paeoniflorin and paeonol. Arch. Pharm. Res. 31, 445–450 (2008). https://doi.org/10.1007/s12272-001-1177-6

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  • DOI: https://doi.org/10.1007/s12272-001-1177-6

Key words

  • Allergy
  • Paeonia lactiflora
  • Paeoniflorin
  • Paeonol