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Melanogenesis inhibitory compounds from Saussureae Radix

Archives of Pharmacal Research volume 31, Article number: 294 (2008) Cite this article

Abstract

Ten compounds were isolated from the EtOAc soluble part of the MeOH extract of Saussureae Radix, with their effects on melanin production also evaluated in B-16 mouse melanoma cell lines stimulated with 3-isobutyl-1-methylxanthine (IBMX), an elevator of cellular cAMP. The compounds were identified as aplotaxene (1), 1β-hydroxy arbusculin A (2), costunolide (3), dehydrocostuslactone (4), 11β,13-dihydrocostunolide (5), reynosin (6), heptadec-(9Z)-enoic acid (7), β-sitosterol (8), linoleic acid methyl ester (9) and betulinic acid methyl ester (10). Compounds 2, 9 and 10 were identified from Saussureae Radix for the first time. Furthermore, compounds 2, 3 and 6 showed potent inhibitory effects on the IBMX-induced melanogenesis, in dose-dependent manners, with IC50 values of 11, 3 and 2.5 μg/mL, respectively. As a positive control, arbutin exhibited an IC50 value of 29 μg/mL.

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Affiliations

  1. College of Pharmacy, Yeungnam University, Gyeongsan, 712-749, Korea

    Ji Young Choi, Eun Hyang Choi, Hee Wook Jung, Joon Seok Oh, Jong Gu Lee, Jong-Keun Son & Seung Ho Lee

  2. College of Pharmacy, Chungbuk National University, Cheongju, 361-763, Korea

    Won-Hee Lee & Youngsoo Kim

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  1. Ji Young Choi
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  2. Eun Hyang Choi
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  3. Hee Wook Jung
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  9. Seung Ho Lee
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Correspondence to Seung Ho Lee.

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Choi, J.Y., Choi, E.H., Jung, H.W. et al. Melanogenesis inhibitory compounds from Saussureae Radix. Arch. Pharm. Res. 31, 294 (2008). https://doi.org/10.1007/s12272-001-1154-0

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  • DOI: https://doi.org/10.1007/s12272-001-1154-0

Key words

  • Saussureae Radix
  • Melanogenesis
  • 1β-hydroxy arbusculin A
  • Costunolide
  • Reynosin