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Evaluation of skin permeation and accumulation profiles of a highly lipophilic fatty ester

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Abstract

The aim was to evaluate the skin permeation and accumulation profiles of a highly lipophilic fatty ester using the combination of various permeation enhancing techniques to study the potential of highly lipophilic fatty esters as local topical agents. Permeation and accumulation profiles of ketorolac stearate (C18:0) were studied using solubility improved formulation, supersaturated solution of permeant in enhancer vehicle, lipophilic receptor solution, enhancer pretreatment, and the removal of stratum corneum and delipidization of skins. Impermeability and minimal skin accumulation of ketorolac stearate could delineate a preliminary possibility for designing safer topical agents without systemic absorption.

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Authors and Affiliations

  1. College of Pharmacy, Yeungnam University, Gyongsan, 712-749, Korea

    Krishna Hari Bhandari, Dong Xun Lee, Madhuri Newa, Jung-Ae Kim, Bong Kyo Yoo, Jong Soo Woo, Han Gon Choi & Chul Soon Yong

  2. Department of Biotechnology, Dongseo University, Busan, 617-716, Korea

    Sung II Yoon & Jung Sun Kim

  3. College of Pharmacy, Seoul National University, Seoul, 151-742, Korea

    Dae Duk Kim

  4. School of Textiles, Yeungnam University, Gyongsan, 712-749, Korea

    Won Seok Lyoo

  5. Division of Pharmaceutical Sciences, Chung-Ang University, Seoul, 156-756, Korea

    Jae Hwi Lee

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  1. Krishna Hari Bhandari
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  2. Dong Xun Lee
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  3. Madhuri Newa
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  4. Sung II Yoon
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  5. Jung Sun Kim
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  6. Dae Duk Kim
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  7. Jung-Ae Kim
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  8. Bong Kyo Yoo
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  9. Jong Soo Woo
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  10. Won Seok Lyoo
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  11. Jae Hwi Lee
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  12. Han Gon Choi
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  13. Chul Soon Yong
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Corresponding authors

Correspondence to Han Gon Choi or Chul Soon Yong.

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Bhandari, K.H., Lee, D.X., Newa, M. et al. Evaluation of skin permeation and accumulation profiles of a highly lipophilic fatty ester. Arch. Pharm. Res. 31, 242–249 (2008). https://doi.org/10.1007/s12272-001-1148-8

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  • DOI: https://doi.org/10.1007/s12272-001-1148-8

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