Skip to main content
Log in

Neue Einzeldomänen-Antikörper-basierte Reagenzien zum Nachweis von PSD-95

  • Anwendungen & Produkte
  • Exzitatorische Synapsen
  • Published:
BIOspektrum Aims and scope

Abstract

Immunofluorescence of the postsynaptic marker proteins PSD-95 is notoriously difficult using conventional antibodies. We describe new reagents based on a small single-domain antibody that allows highly sensitive detection of PSD-95 without special sample treatment.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Literatur

  1. Coley AA, Gao WJ (2018) PSD95: A synaptic protein implicated in schizophrenia or autism? Prog Neuropsychopharmacology Biological Psychiatry 82: 187–194

    Article  CAS  Google Scholar 

  2. Rodríguez-Palmero A, Boerrigter MM, Gómez-Andrés D et al. (2021) DLG4-related synaptopathy: a new rare brain disorder. Genet Med 23: 888–899

    Article  PubMed  Google Scholar 

  3. Kilisch M, Gere-Becker M, Wüstefeld L et al. (2023) Simple and Highly Efficient Detection of PSD95 Using a Nanobody and Its Recombinant Heavy-Chain Antibody Derivatives. Int J Mol Sci 24: 7294

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Sograte-Idrissi S, Schlichterhaerle T, Duque-Afonso CJ et al. (2020) Circumvention of common labelling artefacts using secondary nanobodies. Nanoscale 12: 10226–10239

    Article  CAS  PubMed  Google Scholar 

  5. Dosemeci A, Weinberg RJ, Resse TS, Tao-Cheng JH (2016) The Postsynaptic Density: There Is More than Meets the Eye Front. Synaptic Neurosci 8: 23

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Felipe Opazo.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Opazo, F., Frey, S. Neue Einzeldomänen-Antikörper-basierte Reagenzien zum Nachweis von PSD-95. Biospektrum 29, 649–650 (2023). https://doi.org/10.1007/s12268-023-2037-1

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12268-023-2037-1

Navigation