Abstract
It is a challenge to establish and use model systems for the study of complex neuropsychiatric diseases such as schizophrenia (SZ) and autism spectrum disorder (ASD). The development of induced pluripotent stem cell (iPSC) technologies now offers a promising approach which faithfully represents the varying genetic background of individual patients. Phenotypic analysis of iPSC-derived neurons reveals differences at the level of transcriptomes and calcium signalling allowing for a specific discrimination between SZ and ASD phenotypes.
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Ricarda Stock2015–2017 Masterstudium Molekulare Zellbiologie und Immunologie an der Universität Tübingen. Seit 2018 Promotionsstudium der Molekularen Neurobiologie am Naturwissenschaftlichen und Medizinischen Institut (NMI) an der Universität Tübingen, Reutlingen.
Hansjürgen Volkmer1979–1989 Biologiestudium und Promotion an der Universität Tübingen. 1989–1993 Zentrum für Molekulare Neurobiologie, Hamburg. 1993–1997 Max-Delbrück-Centrum, Berlin-Buch. Seit 1998 Gruppenleiter und Bereichsleiter am Naturwissenschaftlichen und Medizinischen Institut (NMI) an der Universität Tübingen, Reutlingen.
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Stock, R., Volkmer, H. Psychiatrische Erkrankungen mit Stammzelltechnologien verstehen. Biospektrum 26, 46–49 (2020). https://doi.org/10.1007/s12268-020-1321-6
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DOI: https://doi.org/10.1007/s12268-020-1321-6