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Cytochrome P450 — vielseitige Enzyme für Medizin und Biotechnologie

  • Biotechnologie
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Abstract

Cytochromes P450 are heme containing enzymes that catalyze numerous oxidation reactions including hydroxylation of non-activated CH-bonds, epoxidation, dealkylation and even C-C bond cleavage. Along with their broad substrate spectrum, P450s often possess high regio-, chemo-, and stereoselectivity, thereby playing an essential role in metabolism. Due to their versatility P450s are the rising stars in biotechnological applications and synthetic biology.

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Author information

Authors and Affiliations

  1. Institut fur Biochemie, Heinrich-Heine-Universitat Dusseldorf, Universitatsstraße 1, D-40225, Düsseldorf, Deutschland

    Vlada B. Urlacher

  2. Universitat des Saarlandes, Institut fur Biochemie, Campus B2 2, D-66041, Saarbrücken, Deutschland

    Rita Bernhardt

Authors
  1. Vlada B. Urlacher
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  2. Rita Bernhardt
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Corresponding authors

Correspondence to Vlada B. Urlacher or Rita Bernhardt.

Additional information

Vlada B. Urlacher 1988–1993 Biologiestudium an der Staatlichen Universität Taschkent, Usbekistan. 1993–1996 Promotion am Institut für Mikrobiologie, Akademie der Wissenschaft, Usbekistan. 1997–1998 Postdoktorandin am Institut für Technische Biochemie, Universität Stuttgart. 1999–2000 Postdoktorandin am Institut für Biochemie und Biotechnologie, Universität Halle-Wittenberg. 2001–2009 Gruppenleiterin am Institut für Technische Biochemie, Universität Stuttgart; dort 2008 Habilitation für das Fach Molekulare Biotechnologie. Seit 2010 Professorin für Biochemie an der Universität Düsseldorf.

Rita Bernhardt 1969–1973 Biochemiestudium an der Universität Halle-Wittenberg. 1973–1977 Aspirantur an der Staatlichen Lomonossow-Universität Moskau. 1977–1991 Mit -arbeiterin am Zentralinstitut für Molekularbiologie, Berlin-Buch. 1992–1995 Projektleiterin am Max-Delbrück-Centrum, Berlin-Buch. 1995–2016 Lehrstuhlinhaberin für Biochemie an der Universität des Saarlandes. Seit 2016 Seniorprofessorin ebendort.

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Urlacher, V.B., Bernhardt, R. Cytochrome P450 — vielseitige Enzyme für Medizin und Biotechnologie. Biospektrum 25, 715–718 (2019). https://doi.org/10.1007/s12268-019-1303-8

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  • DOI: https://doi.org/10.1007/s12268-019-1303-8

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