Abstract
Advances in protein engineering have made the industrial use of enzymes feasible, though, a more wide-spread application is hampered by the limited stability of enzymes under often required harsh conditions. We developed a protein stabilization technology that involves the in situ cyclization of proteins (INCYPRO) and facilitates the design and semi-synthesis of multicyclic enzymes. These synthetically enhanced durable enzymes add to the current efforts towards a sustainable and green economy.
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Open Access: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits use, duplication, adaption, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Open access funding provided by Vrije Universiteit Amsterdam, The Netherlands.
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Neubacher, S., Hennig, S. & Grossmann, T.N. Organisch-chemisch stabilisierte Enzyme für eine nachhaltige Wirtschaft. Biospektrum 25, 338–339 (2019). https://doi.org/10.1007/s12268-019-1039-5
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DOI: https://doi.org/10.1007/s12268-019-1039-5