Computergestütztes Design mikrobieller Zellfabriken
- 72 Downloads
A key principle for the rational design of cell factories is the stoichiometric coupling of growth and product synthesis. Based on this approach we recently constructed an Escherichia coli strain producing itaconic acid with excellent yields. Furthermore, in a large-scale computational study we demonstrated that coupling of growth and production is, in principle, feasible for almost all metabolites in five major production organisms. These results are of fundamental importance for rational metabolic engineering in biotechnology.
Open Access: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (https://doi.org/creativecommons.org/licenses/by/4.0/), which permits use, duplication, adaption, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Open access funding provided by Max Planck Society.