Abstract
A key principle for the rational design of cell factories is the stoichiometric coupling of growth and product synthesis. Based on this approach we recently constructed an Escherichia coli strain producing itaconic acid with excellent yields. Furthermore, in a large-scale computational study we demonstrated that coupling of growth and production is, in principle, feasible for almost all metabolites in five major production organisms. These results are of fundamental importance for rational metabolic engineering in biotechnology.
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Steffen Klamt Jahrgang 1972. 1992–1998 Studium der Angewandten Systemwissenschaft an der Universität Osnabrück. 1998–2005 Doktorarbeit und 2005–2008 Postdoc am Max-Planck-Institut (MPI) für Dynamik komplexer technischer Systeme, Magdeburg. Promotion 2005 an der Universität Stuttgart. Seit 2009 Forschungsgruppenleiter „Analyse und Redesign Biologischer Netzwerke“ am MPI Magdeburg.
Björn-Johannes Harder Jahrgang 1987. 2008–2013 Biotechnologiestudium an der Universität Braunschweig. 2014–2018 Doktorarbeit und seit 2018 Postdoc am Max-Planck-Institut für Dynamik komplexer technischer Systeme, Magdeburg. Promotion an der Universität Magdeburg.
Axel von Kamp Jahrgang 1972. 1991–1998 Studium der Biologie und Naturwissenschaftlichen Informatik an der Universität Bielefeld. 1998–2002 Promotion an der Dublin City University, Irland. 2003–2007 Postdoc an der Universität Jena. Seit 2007 wissenschaftlicher Mitarbeiter am Max-Planck-Institut für Dynamik komplexer technischer Systeme, Magdeburg.
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Klamt, S., von Kamp, A. & Harder, BJ. Computergestütztes Design mikrobieller Zellfabriken. Biospektrum 25, 156–158 (2019). https://doi.org/10.1007/s12268-019-1015-0
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DOI: https://doi.org/10.1007/s12268-019-1015-0