, Volume 25, Issue 2, pp 156–158 | Cite as

Computergestütztes Design mikrobieller Zellfabriken

  • Steffen KlamtEmail author
  • Axel von Kamp
  • Björn-Johannes Harder
Open Access
Wissenschaft · Methoden Metabolic Engineering


A key principle for the rational design of cell factories is the stoichiometric coupling of growth and product synthesis. Based on this approach we recently constructed an Escherichia coli strain producing itaconic acid with excellent yields. Furthermore, in a large-scale computational study we demonstrated that coupling of growth and production is, in principle, feasible for almost all metabolites in five major production organisms. These results are of fundamental importance for rational metabolic engineering in biotechnology.


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Copyright information

© Die Autoren 2019

Open Access: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits use, duplication, adaption, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Open access funding provided by Max Planck Society.

Authors and Affiliations

  • Steffen Klamt
    • 1
    • 2
    Email author
  • Axel von Kamp
    • 1
  • Björn-Johannes Harder
    • 1
  1. 1.Analyse und Redesign Biologischer NetzwerkeMax-Planck-Institut für Dynamik Komplexer Technischer SystemeMagdeburgDeutschland
  2. 2.Max-Planck-Institut für Dynamik komplexer technischer SystemeMagdeburgDeutschland

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