Abstract
The corticotropin-releasing hormone (CRH) system orchestrates the organism’s stress response including the regulation of adaptive be haviours. Here we describe a novel neuronal circuit, which acts anxiety suppressing and positively modulates dopamine release. This anxiolytic circuit comprises inhibitory CRH-expressing, long-range projection neurons within the extended amygdala. These neurons innervate the ventral tegmental area, a prominent brain reward center that expresses high levels of CRH receptor type 1.
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Nina Dedic 2004–2009 Studium der Molekularen Biotechnologie an der TU Dresden und der TU München. 2010–2015 Promotion an der TU München und am Max-Planck-Institut für Psychiatrie, München. 2015–2017 Postdoc am Max-Planck- Institut für Psychiatrie und am Massachusetts Institute of Technology, Cambridge, USA. Seit 2017 in der präklinischen Forschung bei Sunovion Pharmaceuticals, Marlborough, USA.
Jan M. Deussing Jahrgang 1969. 1988–1995 Studium der Biologie an der Universität Göttingen. 1995–1999 Promotion an der Universität Freiburg. 1996/1997 Forschungsaufenthalt am Massachusetts Institute of Technology, Cambridge, USA. 1999-2000 Postdoc an der Universität Freiburg. 2001–2004 Postdoc am Max-Planck-Institut für Psychiatrie und am Helmholtz Zentrum München. Seit 2004 Leiter der Arbeitsgruppe Molekulare Neurogenetik am Max-Planck-Institut für Psychiatrie.
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Dedic, N., Deussing, J.M. Regulation des Angstverhaltens — zur Rolle neuronaler Netzwerke. Biospektrum 25, 711–714 (2019). https://doi.org/10.1007/s12268-019-0226-8
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DOI: https://doi.org/10.1007/s12268-019-0226-8