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Potenzial von Magnetpartikeln in der automatisierten Biodetektion

  • Wissenschaft · Special: Laborautomation
  • Bioanalytik
  • Published:
BIOspektrum Aims and scope

Abstract

The use of magnetic beads is a common tool for various biotechnological procedures. In laboratory automation, magnetizable particles help to purify cells or biomolecules for subsequent cultivation or analysis. Besides that, many devices and methods evolved using intrinsic properties of the beads to quantify biomolecules. Combination of innovative devices with new methods will allow for high sensitive assays and bear the potential of less process steps for analytical procedures in the future.

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Literatur

  1. Häfeli U, Schütt W, Teller J et al. (1997) Scientific and Clinical Applications of Magnetic Carriers. Springer, Berlin

    Book  Google Scholar 

  2. Miltenyi S, Muller W, Weichel W et al. (1990) High gradient magnetic cell separation with MACS. Cytometry 11:231–238

    Article  PubMed  CAS  Google Scholar 

  3. Gijs MAM (2004) Magnetic bead handling on-chip: new opportunities for analytical applications. Microfluid Nanofluid 1:22–40

    CAS  Google Scholar 

  4. Liu C, Stakenborg T, Peeters S et al. (2009) Cell manipulation with magnetic particles toward microfluidic cytometry. J Appl Phys 105, doi: 10.1063/1.3116091

  5. Baselt DR, Lee GU, Natesan M et al. (1998) A biosensor based on magnetoresistance technology. Biosens Bioelectron 13:731–739

    Article  PubMed  CAS  Google Scholar 

  6. Wang H, Chen Y, Hassibi A et al. (2009) A Frequency-Shift CMOS Magnetic Biosensor Array with Single-Bead Sensitivity and No External Magnet. IEEE International Solid-State Circuits Conference digest of technical papers, 438–439

    Google Scholar 

  7. Chung SH, Hoffmann A, Bader SD et al. (2004) Biological sensors based on Brownian relaxation of magnetic nano -particles. Appl Phys Lett 85:2971–2973

    Article  CAS  Google Scholar 

  8. Reis C, Siegert C, Dimitriadis N (2014) Magneto-hydrodynamic focusing magneto-hydrodynamic focusing: a novel method for highly sensitive biomolecule detection. Biomed Tech 59:117–120

    Google Scholar 

  9. Bruls DM, Evers TH, Kahlman JAH et al. (2009) Rapid integrated biosensor for multiplexed immunoassays based on actuated magnetic nanoparticles. Lab Chip 9:3504–3510

    Article  PubMed  CAS  Google Scholar 

  10. Adamcova M, Šimko F (2018) Multiplex biomarker approach to cardiovascular diseases. Acta Pharmacol Sin, doi: 10.1038/aps.2018.29

    Google Scholar 

  11. Stolarski M (2011) Die Magnetfeldüberlagerte Zentrifugation: Ein neues hybrides Trennverfahren zur Selektiven Bioseparation. Dissertation, Karlsruhe Institut für Technologie (KIT).

    Google Scholar 

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Authors and Affiliations

  1. Fraunhofer-Institut für Produktionstechnik und Automatisierung (IPA), Projektgruppe für Automatisierung in der Medizin und Biotechnologie, Theodor-Kutzer-Ufer 1–3, Cubex41, D-68167, Mannheim, Deutschland

    Christian Reis, Stefan Scheuermann & Caroline von Wulffen

Authors
  1. Christian Reis
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  2. Stefan Scheuermann
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  3. Caroline von Wulffen
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Corresponding author

Correspondence to Christian Reis.

Additional information

Fraunhofer-Projektgruppe für Automatisierung in der Medizin und Biotechnologie (PAMB) Die Gruppe Labormechatronik und Prozesstechnik des Fraunhofer-IPA ist Teil der Projektgruppe für Automatisierung in der Medizin und Biotechnologie mit Sitz am Universitätsklinikum Mannheim. Wir entwickeln bioanalytische Systeme für den Einsatz in biotechnologischen und klinischen Umgebungen. Die Hauptaktivitäten konzentrieren sich dabei auf die Prozessentwicklung, Testung und die gerätetechnische Umsetzung. Daneben werden automatisierte Systeme entwickelt, die das Ausgangsmaterial (z. B. DNA, Proteine oder Zellen) aus unterschiedlichen Probenmaterialien für die Bioanalytik bereitstellen.

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Reis, C., Scheuermann, S. & von Wulffen, C. Potenzial von Magnetpartikeln in der automatisierten Biodetektion. Biospektrum 24, 509–512 (2018). https://doi.org/10.1007/s12268-018-0954-1

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  • DOI: https://doi.org/10.1007/s12268-018-0954-1

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