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Lichtstrukturierte Matrizen für die räumlich-zeitliche Proteinanordnung

  • Wissenschaft
  • Optochemische Biologie und photosensitive 3D-Hydrogele
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Abstract

In vivo, cells can grow in 3D and significantly differ from cells grown in 2D. Imitating an extracellular microenvironment, 3D cell culture platforms using dynamic hydrogels have emerged, which can be altered by external stimuli, such as light, to mimic the chemical and physical properties of the native cellular environment. Photo-sensitive matrices enable the non-invasive, on-demand assembly of proteins and allow them to take influence on cells in real-time with high accuracy.

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Author information

Authors and Affiliations

  1. Institut für Biochemie, Biocenter, Goethe-Universität Frankfurt, Max-von-Laue-Straße 9, D-60438, Frankfurt a. M., Deutschland

    Ralph Wieneke

Authors
  1. Ralph Wieneke
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Correspondence to Ralph Wieneke.

Additional information

Ralph Wieneke1999–2005 Chemiestudium an der Universität Marburg, 2009 Promotion in bioorganischer Chemie unter der Leitung von Prof. Dr. A. Geyer. 2009 Gastwissenschaftler an der Universität Göttingen im Labor von Prof. Dr. C. Steinem. 2010–2014 Postdoktorand an der Universität Frankfurt a. M. unter der Leitung von Prof. Dr. R. Tampé. Seit 2014 eigenständige Arbeiten auf dem Gebiet der optochemischen Biologie mit Fokus auf der Entwicklung von molekularen Werkzeugen zur Untersuchung und Manipulation von Membran-assoziierten Prozessen.

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Wieneke, R. Lichtstrukturierte Matrizen für die räumlich-zeitliche Proteinanordnung. Biospektrum 24, 471–474 (2018). https://doi.org/10.1007/s12268-018-0947-0

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  • DOI: https://doi.org/10.1007/s12268-018-0947-0

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