Abstract
Indole is an important compound in nature and is present in many pathways. First, an overview is given on the oxidative conversions of indole and respective products formed. A focus is put on the formation of pure indigo and some derivatives. Thus, flavin-dependent monooxygenases (styrene epoxidases) were employed which allow the selective oxygenation of indole leading to pure products without the formation of by-pro - ducts as indirubin or isoindigo.
Similar content being viewed by others
Literatur
Sadauskas M, Vaitekūnas J, Gasparavičiūtė R et al. (2017) Indole biodegradation in Acinetobacter sp. strain O153: genetic and biochemical characterization. Appl Environ Microbiol 83, doi: 10.1128/AEM.01453-17
Dua A, Chauhan K, Pathak H (2014) Biotransformation of indigo pigment by indigenously isolated Pseudomonas sp. HAV-1 and assessment of its antioxidant property. Biotechnol Res Int, doi: 10.1155/2014/109249
Glowacki ED, Voss G, Leonat L et al. (2012) Indigo and tyrian purple–from ancient natural dyes to modern organic semiconductors. Isr J Chem 52:540–551
He B, Pun AB, Zherebetskyy D et al. (2014) New form of an old natural dye: bay-annulated indigo (BAI) as an excellent electron accepting unit for high performance organic semi - conductors. J Am Chem Soc 136:15093–15101
Heine T, Tucker K, Okonkwo N et al. (2017) Engineering styrene monooxygenase for biocatalysis: reductase-epoxidase fusion proteins. Appl Biochem Biotechnol 181:1590–1610
Riedel A, Heine T, Westphal AH et al. (2015) Catalytic and hydrodynamic properties of styrene monooxygenases from Rhodococcus opacus 1CP are modulated by cofactor binding. AMB Express 5:112
Tischler D, Gröning JAD, Kaschabek SR et al. (2012) Onecomponent styrene monooxygenases: an evolutionary view on a rare class of flavoproteins. Appl Biochem Biotechnol 167:931–944
Li QS, Schwaneberg U, Fischer P et al. (2000) Directed evolution of the fatty-acid hydroxylase P450 BM-3 into an indole-hydroxylating catalyst. Chemistry 6:1531–1536
Paul CE, Tischler D, Riedel A et al. (2015) Nonenzymatic regeneration of styrene monooxygenase for catalysis. ACS Catal 5:2961–2965
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Heine, T., Großmann, C., Hofmann, S. et al. Enzymgesteuerte Indigoproduktion. Biospektrum 24, 446–448 (2018). https://doi.org/10.1007/s12268-018-0938-1
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12268-018-0938-1