Abstract
The creation of self-replicating minimal cells is a major goal in synthetic biology and origin of life research. In order to be considered alive, a minimal cell must have several characteristics such as the ability to reproduce and adapt to its environment. Our research focuses on genetic replication and evolution in such minimal systems.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
Literatur
Schwille P, Spatz J, Landfester K et al. (2018) MaxSynBio–Avenues towards creating cells from the bottom up. Angew Chem Int Ed Engl, doi: 10.1002/anie.201802288
Luisi PL, Ferri F, Stano P (2006) Approaches to semisynthetic minimal cells: a review. Naturwissenschaften 93:1–13
Higgs PG, Lehman N (2015) The RNA world: molecular cooperation at the origins of life. Nat Rev Genet 16:7–17
Patel BH, Percivalle C, Ritson DJ et al. (2015) Common origins of RNA, protein and lipid precursors in a cyanosulfidic protometabolism. Nat Chem 7:301–307
Mutschler H, Wochner A, Holliger P (2015) Freeze-thaw cycles as drivers of complex ribozyme assembly. Nat Chem 7:502–508
Litschel T, Ganzinger KA, Movinkel T et al. (2018) Freeze-thaw cycles induce content exchange between model protocells. New J Phys 20:055008
Oparin AI (1965) The origin of life and the origin of enzymes. Adv Enzymol Relat Areas Mol Biol 27:347–380
Drobot B, Iglesias-Artola JM, Le Vay K et al. (2018) Compartmentalized RNA catalysis in membrane–free coacervate protocells. bioRxiv, doi: 10.1101/273417
Jewett MC, Forster AC (2010) Update on designing and building minimal cells. Curr Opin Biotechnol 21:697–703
Ichihashi N, Usui K, Kazuta Y et al. (2013) Darwinian evolution in a translation-coupled RNA replication system within a cell-like compartment. Nat Commun 4:2494
van Nies P, Westerlaken I, Blanken D et al. (2018) Self-replication of DNA by its encoded proteins in liposome- based synthetic cells. Nat Commun 9:1583
Author information
Authors and Affiliations
Corresponding author
Additional information
Laura I. Weise 2011–2014 Bachelorstudium Chemie und Biochemie und 2014–2017 Masterstudium Biochemie an der LMU München. Seit 2017 Promotion am Max-Planck-Institut für Biochemie, Martinsried.
Kai Libicher 2011–2014 Bachelor- und 2014–2017 Masterstudium der Molekularen Biotechnologie an der TU München. Seit 2017 Promotion am Max- Planck-Institut für Biochemie, Martinsried, über das Graduiertenprogramm der International- Max-Planck-Research- School (IMPRS).
Hannes Mutschler 2001–2006 Biophysikstudium an der HU Berlin und der ETH Zürich, Schweiz. 2007–2011 Promotion am Max-Planck-Institut für medizinische Forschung, Heidelberg. 2012–2016 Postdoktorand am MRC Laboratory of Molecular Biology, Cambridge, UK. Seit 2016 unabhängiger Nachwuchsgruppenleiter am Max-Planck- Institut für Biochemie, Martinsried.
Rights and permissions
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits use, duplication, adaption, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Open access funding provided by Max Planck Society.
About this article
Cite this article
Weise, L.I., Libicher, K. & Mutschler, H. Copy, paste, repeat — über die Synthese von Minimalzellen. Biospektrum 24, 365–367 (2018). https://doi.org/10.1007/s12268-018-0927-4
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12268-018-0927-4