Genetische Aspekte bei Alkoholismus
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Studies in twins demonstrate major genetic influences in the development of alcohol use disorders (AUD) such as addiction. Candidate studies and genome-wide association studies (GWAS) have identified numerous candidate genes for excessive alcohol consumption and AUD. Here we present a convergent functional genetics approach which is a translational methodology that integrates multiple lines of evidence from studies in human and animal models to get a better understanding of the genetics of AUD.
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- Roussotte FF, Gutman BA, Hibar DP et al. (2013) A single nucleotide polymorphism associated with reduced alcohol intake in the RASGRF2 gene predicts larger cortical volumes but faster longitudinal ventricular expansion in the elderly. Front Aging Neurosci 5:93CrossRefPubMedPubMedCentralGoogle Scholar