Synthese von schwefelhaltigen Metallkofaktoren und Thionukleosiden in tRNA
The synthesis of sulfur-containing biomolecules is a complex process that involves the activation of sulfur. In particular, L-cysteine desulfurases serve as primary sulfur-providing proteins for biomolecules including Fe-S clusters, thiamin, biotin, lipoic acid, molybdenum cofactor (Moco), and thiolated nucleosides in tRNA. The pathways for the sulfur insertion for Fe-S cluster assembly, Moco biosynthesis and thiomodifications of tRNA are introduced and common principles are revealed.
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- Leimkühler S, Bühning M, Beilschmidt L (2017) Shared sulfur mobilization routes for tRNA thiolation and molybdenum cofactor biosynthesis in prokaryotes and eukaryotes. Biomolecules 7, doi: 10.3390/biom7010005Google Scholar