Native Massenspektrometrie für die Proteinstrukturanalytik
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In native mass spectrometry sample handling and measuring conditions are optimized to retain non-covalent interactions, allowing the detailed analysis of protein-protein and protein-ligand interactions. Thereby, stoichiometry, structure and dynamics of protein complexes can be studied, also by means of additional gas-phase techniques. Coupling native mass spectrometry to X-ray free-electron lasers potentially opens new routes in protein structure analysis.
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