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BIOspektrum

, Volume 24, Issue 2, pp 164–167 | Cite as

Native Massenspektrometrie für die Proteinstrukturanalytik

  • Johannes Heidemann
  • Boris Krichel
  • Charlotte Uetrecht
Wissenschaft · Special: Proteinanalytik Proteinkomplexforschung
  • 33 Downloads

Abstract

In native mass spectrometry sample handling and measuring conditions are optimized to retain non-covalent interactions, allowing the detailed analysis of protein-protein and protein-ligand interactions. Thereby, stoichiometry, structure and dynamics of protein complexes can be studied, also by means of additional gas-phase techniques. Coupling native mass spectrometry to X-ray free-electron lasers potentially opens new routes in protein structure analysis.

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Copyright information

© Springer-Verlag GmbH Deutschland, ein Teil von Springer Nature 2018

Authors and Affiliations

  • Johannes Heidemann
    • 1
  • Boris Krichel
    • 1
  • Charlotte Uetrecht
    • 1
    • 2
  1. 1.Heinrich-Pette-InstitutLeibniz-Institut für Experimentelle VirologieHamburgGermany
  2. 2.European XFEL GmbHSchenefeldGermany

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