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BIOspektrum

, Volume 24, Issue 2, pp 146–148 | Cite as

Netzbildung als Abwehrstrategie des menschlichen Körpers

  • Judith Wendler
  • Heike Brötz-Oesterhelt
  • Jan Wehkamp
Wissenschaft Defensine
  • 17 Downloads

Abstract

The human organism is protected against commensal and pathogenic microbes by antimicrobial molecules of the innate immune system. The human beta defensin 1 (hBD1) is one of the most prominent antimicrobial molecules and–in contrast to other defensins – constantly expressed by epithelial cells. A recent study displayed a new mechanism of hBD1: Besides bacterial cell envelope damage, it can form a so far unknown net-like structure. Bacteria can be entrapped in these nets providing a physical barrier which is independent of antimicrobial activity.

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Copyright information

© Springer-Verlag GmbH Deutschland, ein Teil von Springer Nature 2018

Authors and Affiliations

  1. 1.Innere Medizin 1Universitätsklinikum TübingenTübingenGermany
  2. 2.Abteilung Für Mikrobielle Wirkstoffe, Institut Für Mikrobiologie Und InfektionsmedizinUniversität TübingenTübingenGermany

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