Shark attack: Haiantikörper für Biomedizin und Biotechnologie
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The adaptive immune system of sharks comprises a very interesting antibody isotype named immunoglobulin new antigen receptor (IgNAR). In contrast to classical antibodies, the antigen binding site of the heavy chain only immunoglobulin is formed by a single variable domain, referred to as vNAR (variable domain of IgNAR). Due to its small size combined with a high stability and selectivity to a cognate antigen, vNAR domains emerged as promising molecules for biotechnological and biomedical applications.
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- Kovaleva M, Johnson K, Steven J et al. (2017) Therapeutic potential of shark anti-ICOSL vNAR domains is exemplified in a murine model of autoimmune non-infectious uveitis. Front Immunol 8 (doi: 10.3389/fimmu.2017.01121)Google Scholar
- Ubah OC, Steven J, Kovaleva M et al. (2017) Novel, antihTNF- a variable new antigen receptor formats with enhanced neutralizing potency and multifunctionality, generated for therapeutic development. Front Immunol 8 (doi: 10.3389/fimmu.2017.01780)Google Scholar