, Volume 24, Issue 2, pp 138–141 | Cite as

Built to last – über die intrazelluläre Stabilität von Koenzymen

  • Johannes Hartl
  • Julia A. Vorholt
Wissenschaft Metabolismus


Coenzymes drive key metabolic processes. In the cell, they are challenged by intrinsic chemical reactivity, their high usage, and damaging enzyme promiscuity. Nevertheless, quantification of coenzyme turnover shows that maintenance of most functional coenzymes is independent of degradation, highlighting their longevity, which requires biosynthesis only to compensate for dilution by growth.


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Copyright information

© Springer-Verlag GmbH Deutschland, ein Teil von Springer Nature 2018

Authors and Affiliations

  1. 1.Institut für MikrobiologieEth ZürichZürichSchweiz

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