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BIOspektrum

, Volume 24, Issue 2, pp 134–137 | Cite as

Das RNA-Exosom – eine molekulare Maschine für den RNA-Abbau

  • Sebastian Falk
  • Elena Conti
Open Access
Wissenschaft Genexpression
  • 47 Downloads

Abstract

The exosome is an evolutionary conserved macromolecular complex that degrades RNAs from the 3′ end. It is present both in the cytoplasm and the nucleus, where it degrades different types of RNAs in yeast, human cells and other eukaryotes studied to date. The exosome is involved in the turnover of mRNAs, ncRNA and tRNAs, but also in the surveillance of faulty pre-mRNAs. In addition to its degradative function it is also involved in the controlled processing of e. g. rRNAs.

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Copyright information

© Die Autoren 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits use, duplication, adaption, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Open access funding provided by Max Planck Society.

Authors and Affiliations

  1. 1.Abteilung für Zelluläre StrukturbiologieMax-Planck-Institut für BiochemieMartinsriedGermany

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