Abstract
The exosome is an evolutionary conserved macromolecular complex that degrades RNAs from the 3′ end. It is present both in the cytoplasm and the nucleus, where it degrades different types of RNAs in yeast, human cells and other eukaryotes studied to date. The exosome is involved in the turnover of mRNAs, ncRNA and tRNAs, but also in the surveillance of faulty pre-mRNAs. In addition to its degradative function it is also involved in the controlled processing of e. g. rRNAs.
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Elena Conti 1996 Promotion am Imperial College in London, UK. 1997–1999 Postdoktorandin bei Prof. Dr. J. Kuriyan an der Rockefeller University, New York, USA. 1999–2007 Gruppenleiterin am EMBL Heidelberg. Seit 2007 Direktorin der Abteilung „Zelluläre Strukturbiologie“ am Max- Planck-Institut für Biochemie, Martinsried.
Sebastian Falk 2001–2006 Biochemiestudium an der Uni - versität Bayreuth. 2007–2011 Promotion bei Prof. Dr. I. Sinning am Biochemiezentrum der Universität Heidelberg. Seit 2011 Postdoktorand bei Prof. Dr. E. Conti am Max-Planck-Institut für Biochemie, Martinsried.
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Falk, S., Conti, E. Das RNA-Exosom – eine molekulare Maschine für den RNA-Abbau. Biospektrum 24, 134–137 (2018). https://doi.org/10.1007/s12268-018-0896-7
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DOI: https://doi.org/10.1007/s12268-018-0896-7