BIOspektrum

, Volume 24, Issue 1, pp 20–22 | Cite as

Wie die Zelle ihre Kernporen aufbaut

  • Paola De Magistris
  • Rabia Suluyayla
  • Wolfram Antonin
Wissenschaft Kernporenkomplexe
  • 10 Downloads

Abstract

Nuclear pore complexes mediate the exchange of macromolecules between cytoplasm and nuclear interior. These complexes assemble from more than 500 individual nucleoporins and integrate into the double membrane structure of the nuclear envelope at the end of mitosis and in interphase via different pathways. Despite their universal function in all nucleated cells mutations in nucleoporins cause tissue specific disease phenotypes but the underlying molecular mechanisms are often unclear.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. [1]
    Beck M, Hurt E (2017) The nuclear pore complex: understanding its function through structural insight. Nat Rev Mol Cell Biol 18:73–89CrossRefPubMedGoogle Scholar
  2. [2]
    Franz C, Walczak R, Yavuz S et al. (2007) MEL-28/ELYS is required for the recruitment of nucleoporins to chromatin and postmitotic nuclear pore complex assembly. EMBO Rep 8:165–172CrossRefPubMedPubMedCentralGoogle Scholar
  3. [3]
    Vollmer B, Lorenz M, Moreno-Andres D et al. (2015) Nup153 recruits the Nup107-160 complex to the inner nuclear membrane for interphasic nuclear pore complex assembly. Dev Cell 33:717–728CrossRefPubMedGoogle Scholar
  4. [4]
    Braun DA, Sadowski CE, Kohl S et al. (2016) Mutations in nuclear pore genes NUP93, NUP205 and XPO5 cause steroidresistant nephrotic syndrome. Nat Genet 48:457–465CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer-Verlag GmbH Deutschland, ein Teil von Springer Nature 2018

Authors and Affiliations

  • Paola De Magistris
    • 1
  • Rabia Suluyayla
    • 1
  • Wolfram Antonin
    • 1
  1. 1.Institut für Biochemie und Molekulare ZellbiologieUniversitätsklinikum AachenAachenDeutschland

Personalised recommendations