, Volume 24, Issue 1, pp 12–15 | Cite as

Zirkuläre RNAs: neue Spieler im Kreise der Genregulation

  • Laura Santer
  • Christian Bär
  • Thomas Thum
Wissenschaft Nicht-codierende RNAs


High throughput whole transcriptome sequencing led to the discovery of a new class of non-coding RNAs: circular RNAs (circRNAs). Such single-stranded continuous loop RNAs exist for thousands of genes. Here, we present an overview of circRNA discovery and formation. We sum up some circRNA detection methods and highlight different molecular mechanisms of action. However, circRNA functional characterization is still at its very beginning and thus an increasing research field in our and other groups.


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Copyright information

© Springer-Verlag GmbH Deutschland, ein Teil von Springer Nature 2018

Authors and Affiliations

  1. 1.Institut für Molekulare und Translationale TherapiestrategienMedizinische Hochschule HannoverHannoverDeutschland

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