Zirkuläre RNAs: neue Spieler im Kreise der Genregulation
- 42 Downloads
High throughput whole transcriptome sequencing led to the discovery of a new class of non-coding RNAs: circular RNAs (circRNAs). Such single-stranded continuous loop RNAs exist for thousands of genes. Here, we present an overview of circRNA discovery and formation. We sum up some circRNA detection methods and highlight different molecular mechanisms of action. However, circRNA functional characterization is still at its very beginning and thus an increasing research field in our and other groups.
Unable to display preview. Download preview PDF.
- Piwecka M, Glažar P, Hernandez-Miranda LR et al. (2017) Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function. Science 357, doi: 10.1126/science.aam8526Google Scholar
- Fan X, Weng X, Zhao Y (2017) Circular RNAs in cardiovascular disease: an overview. Biomed Res Int, doi: 10.1155/2017/5135781Google Scholar